FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080499812> ?p ?o ?g. }

• W2080499812 endingPage "267" @default.
• W2080499812 startingPage "261" @default.
• W2080499812 abstract "There are differences in the distribution and length of HBV CpG islands and the viral mutations contribute greatly to the development of HBV-related diseases. However, little is known regarding the effects of such difference and mutations in HBV genotypes B and C sequences on the regulation of HBV gene expression and their clinical outcomes. To study the distribution, length and genetic trait of CpG islands in normal and mutant sequences of HBV genotypes B and C, 320 HBV isolates from Chinese patients were retrieved from GenBank. Programs CLUSTALX 1.83 and MethPrimer were employed to perform multiple sequence alignments and to predict CpG islands, respectively. 72.0% genotype B isolates contained three conventional CpG islands, and 76.1% genotype C only contained CpG islands II and III. 14.6% genotype B and 7.5% genotype C contained three novel CpG islands. In genotype B, lengths of conventional CpG islands between normal and mutant isolates exhibited substantial variations, but in genotype C, those were relatively stable. CpG island II could be “truncated” or “split”. “Truncated” region mutations were associated with structural and functional abnormalities of HBV genes. Rate of “split” CpG island II in genotype B was much higher than that in genotype C. In the majority of isolates from HCC and HBV–ACLF, genotype C lacked CpG island I and novel islands. Distribution, length and genetic trait of CpG islands in HBV genotypes B and C might affect their methylation status, and further affect regulation of HBV gene expression, leading to different clinical outcomes." @default.
• W2080499812 created "2016-06-24" @default.
• W2080499812 creator A5012725647 @default.
• W2080499812 creator A5026138811 @default.
• W2080499812 creator A5037458478 @default.
• W2080499812 creator A5038897717 @default.
• W2080499812 creator A5040258718 @default.
• W2080499812 creator A5049352152 @default.
• W2080499812 creator A5051534637 @default.
• W2080499812 creator A5053142661 @default.
• W2080499812 creator A5055139463 @default.
• W2080499812 creator A5059668825 @default.
• W2080499812 creator A5067528057 @default.
• W2080499812 creator A5084345560 @default.
• W2080499812 date "2015-05-01" @default.
• W2080499812 modified "2023-10-08" @default.
• W2080499812 title "CpG islands of hepatitis B virus genome isolated from Chinese patients" @default.
• W2080499812 cites W1980730796 @default.
• W2080499812 cites W2004078197 @default.
• W2080499812 cites W2006048765 @default.
• W2080499812 cites W2026510478 @default.
• W2080499812 cites W2081022491 @default.
• W2080499812 cites W2081556170 @default.
• W2080499812 cites W2099238509 @default.
• W2080499812 cites W2103458510 @default.
• W2080499812 cites W2124731827 @default.
• W2080499812 cites W2142786064 @default.
• W2080499812 cites W2149606497 @default.
• W2080499812 cites W2162292699 @default.
• W2080499812 cites W2162645287 @default.
• W2080499812 cites W2165934724 @default.
• W2080499812 cites W2167699956 @default.
• W2080499812 cites W2327856202 @default.
• W2080499812 cites W3150298192 @default.
• W2080499812 doi "https://doi.org/10.1016/j.gene.2015.02.036" @default.
• W2080499812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25688883" @default.
• W2080499812 hasPublicationYear "2015" @default.
• W2080499812 type Work @default.
• W2080499812 sameAs 2080499812 @default.
• W2080499812 citedByCount "4" @default.
• W2080499812 countsByYear W20804998122016 @default.
• W2080499812 countsByYear W20804998122017 @default.
• W2080499812 countsByYear W20804998122021 @default.
• W2080499812 countsByYear W20804998122022 @default.
• W2080499812 crossrefType "journal-article" @default.
• W2080499812 hasAuthorship W2080499812A5012725647 @default.
• W2080499812 hasAuthorship W2080499812A5026138811 @default.
• W2080499812 hasAuthorship W2080499812A5037458478 @default.
• W2080499812 hasAuthorship W2080499812A5038897717 @default.
• W2080499812 hasAuthorship W2080499812A5040258718 @default.
• W2080499812 hasAuthorship W2080499812A5049352152 @default.
• W2080499812 hasAuthorship W2080499812A5051534637 @default.
• W2080499812 hasAuthorship W2080499812A5053142661 @default.
• W2080499812 hasAuthorship W2080499812A5055139463 @default.
• W2080499812 hasAuthorship W2080499812A5059668825 @default.
• W2080499812 hasAuthorship W2080499812A5067528057 @default.
• W2080499812 hasAuthorship W2080499812A5084345560 @default.
• W2080499812 hasConcept C104317684 @default.
• W2080499812 hasConcept C135763542 @default.
• W2080499812 hasConcept C140173407 @default.
• W2080499812 hasConcept C150194340 @default.
• W2080499812 hasConcept C159047783 @default.
• W2080499812 hasConcept C190727270 @default.
• W2080499812 hasConcept C2522874641 @default.
• W2080499812 hasConcept C2780593183 @default.
• W2080499812 hasConcept C33288867 @default.
• W2080499812 hasConcept C54355233 @default.
• W2080499812 hasConcept C79029880 @default.
• W2080499812 hasConcept C86803240 @default.
• W2080499812 hasConceptScore W2080499812C104317684 @default.
• W2080499812 hasConceptScore W2080499812C135763542 @default.
• W2080499812 hasConceptScore W2080499812C140173407 @default.
• W2080499812 hasConceptScore W2080499812C150194340 @default.
• W2080499812 hasConceptScore W2080499812C159047783 @default.
• W2080499812 hasConceptScore W2080499812C190727270 @default.
• W2080499812 hasConceptScore W2080499812C2522874641 @default.
• W2080499812 hasConceptScore W2080499812C2780593183 @default.
• W2080499812 hasConceptScore W2080499812C33288867 @default.
• W2080499812 hasConceptScore W2080499812C54355233 @default.
• W2080499812 hasConceptScore W2080499812C79029880 @default.
• W2080499812 hasConceptScore W2080499812C86803240 @default.
• W2080499812 hasFunder F4320321001 @default.
• W2080499812 hasIssue "2" @default.
• W2080499812 hasLocation W20804998121 @default.
• W2080499812 hasLocation W20804998122 @default.
• W2080499812 hasOpenAccess W2080499812 @default.
• W2080499812 hasPrimaryLocation W20804998121 @default.
• W2080499812 hasRelatedWork W2011988545 @default.
• W2080499812 hasRelatedWork W2026510478 @default.
• W2080499812 hasRelatedWork W2046342816 @default.
• W2080499812 hasRelatedWork W2094158947 @default.
• W2080499812 hasRelatedWork W2123238153 @default.
• W2080499812 hasRelatedWork W2144473770 @default.
• W2080499812 hasRelatedWork W248460155 @default.
• W2080499812 hasRelatedWork W2582088144 @default.
• W2080499812 hasRelatedWork W2809870307 @default.
• W2080499812 hasRelatedWork W3096866312 @default.
• W2080499812 hasVolume "561" @default.

• next