FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080505830> ?p ?o ?g. }

• W2080505830 endingPage "339" @default.
• W2080505830 startingPage "332" @default.
• W2080505830 abstract "In our previous work, a new kind of pH-sensitive hydrogel based on poly (lactic acid) (PLA), methoxyl poly (ethylene glycol) (MPEG) and itaconic acid (IA) was prepared by heat-initiated free radical polymerization without any organic solvent. For further application, the safety of prepared copolymers and hydrogels was evaluated in vitro and in vivo in this paper. In vitro toxicity evaluation of MPEG-PLA-AC (PLE-AC) copolymers included hemolytic test and cytotoxicity which were evaluated by cell viability assay using HEK293 cells. In vivo acute toxicity tests and histopathological study of PLE-AC copolymers were carried out on BALB/c mice which were administrated copolymers (1 g/kg b.w.) intravenously. In acute toxicity test, the mice were observed continuously for 7 days, their body weight obtained everyday, at last the mice were sacrificed for the following study: the blood of the mice was assigned for blood chemistry and routine analysis, the heart, liver, spleen, lung, and kidneys were used for histopathological study. In acute oral toxicity test, mice were orally administered with a total 15 g/kg body weight (b.w.) of P(LE-IA-MEG) hydrogels, and were observed continuously for 14 days. For histopathologic study, samples including heart, liver, lung, kidneys, spleen, stomach, and intestine, were histochemically prepared and stained with hematoxylin-eosin for histopathologic examination. All results indicated that the PLE-AC copolymers and pH-sensitive hydrogels were non-toxic. Therefore it might be used as a safe candidate for drug delivery system." @default.
• W2080505830 created "2016-06-24" @default.
• W2080505830 creator A5005878202 @default.
• W2080505830 creator A5016477184 @default.
• W2080505830 creator A5026906414 @default.
• W2080505830 creator A5050088429 @default.
• W2080505830 creator A5059631700 @default.
• W2080505830 date "2012-10-01" @default.
• W2080505830 modified "2023-09-27" @default.
• W2080505830 title "Preliminary assessment of the safety evaluation of novel pH-sensitive hydrogel" @default.
• W2080505830 cites W1541839544 @default.
• W2080505830 cites W1982333375 @default.
• W2080505830 cites W1982657479 @default.
• W2080505830 cites W1996249441 @default.
• W2080505830 cites W2000864034 @default.
• W2080505830 cites W2005454227 @default.
• W2080505830 cites W2006246299 @default.
• W2080505830 cites W2006743062 @default.
• W2080505830 cites W2008597360 @default.
• W2080505830 cites W2009881105 @default.
• W2080505830 cites W2010219666 @default.
• W2080505830 cites W2019718881 @default.
• W2080505830 cites W2024313626 @default.
• W2080505830 cites W2028926100 @default.
• W2080505830 cites W2032534436 @default.
• W2080505830 cites W2039587843 @default.
• W2080505830 cites W2043104916 @default.
• W2080505830 cites W2043395983 @default.
• W2080505830 cites W2045701720 @default.
• W2080505830 cites W2047340030 @default.
• W2080505830 cites W2048829256 @default.
• W2080505830 cites W2062513135 @default.
• W2080505830 cites W2062811185 @default.
• W2080505830 cites W2065698339 @default.
• W2080505830 cites W2075825597 @default.
• W2080505830 cites W2093113133 @default.
• W2080505830 cites W2094061696 @default.
• W2080505830 cites W2102583209 @default.
• W2080505830 cites W2103097995 @default.
• W2080505830 cites W2107092681 @default.
• W2080505830 cites W2124767164 @default.
• W2080505830 cites W2131808910 @default.
• W2080505830 cites W2144081123 @default.
• W2080505830 doi "https://doi.org/10.1016/j.ejpb.2012.07.013" @default.
• W2080505830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22885157" @default.
• W2080505830 hasPublicationYear "2012" @default.
• W2080505830 type Work @default.
• W2080505830 sameAs 2080505830 @default.
• W2080505830 citedByCount "15" @default.
• W2080505830 countsByYear W20805058302013 @default.
• W2080505830 countsByYear W20805058302014 @default.
• W2080505830 countsByYear W20805058302015 @default.
• W2080505830 countsByYear W20805058302017 @default.
• W2080505830 countsByYear W20805058302018 @default.
• W2080505830 countsByYear W20805058302019 @default.
• W2080505830 countsByYear W20805058302021 @default.
• W2080505830 crossrefType "journal-article" @default.
• W2080505830 hasAuthorship W2080505830A5005878202 @default.
• W2080505830 hasAuthorship W2080505830A5016477184 @default.
• W2080505830 hasAuthorship W2080505830A5026906414 @default.
• W2080505830 hasAuthorship W2080505830A5050088429 @default.
• W2080505830 hasAuthorship W2080505830A5059631700 @default.
• W2080505830 hasConcept C108586683 @default.
• W2080505830 hasConcept C116263406 @default.
• W2080505830 hasConcept C125473707 @default.
• W2080505830 hasConcept C142724271 @default.
• W2080505830 hasConcept C150903083 @default.
• W2080505830 hasConcept C178790620 @default.
• W2080505830 hasConcept C185592680 @default.
• W2080505830 hasConcept C188027245 @default.
• W2080505830 hasConcept C203014093 @default.
• W2080505830 hasConcept C204232928 @default.
• W2080505830 hasConcept C207001950 @default.
• W2080505830 hasConcept C2777516009 @default.
• W2080505830 hasConcept C2780931953 @default.
• W2080505830 hasConcept C29730261 @default.
• W2080505830 hasConcept C71924100 @default.
• W2080505830 hasConcept C86803240 @default.
• W2080505830 hasConcept C98274493 @default.
• W2080505830 hasConceptScore W2080505830C108586683 @default.
• W2080505830 hasConceptScore W2080505830C116263406 @default.
• W2080505830 hasConceptScore W2080505830C125473707 @default.
• W2080505830 hasConceptScore W2080505830C142724271 @default.
• W2080505830 hasConceptScore W2080505830C150903083 @default.
• W2080505830 hasConceptScore W2080505830C178790620 @default.
• W2080505830 hasConceptScore W2080505830C185592680 @default.
• W2080505830 hasConceptScore W2080505830C188027245 @default.
• W2080505830 hasConceptScore W2080505830C203014093 @default.
• W2080505830 hasConceptScore W2080505830C204232928 @default.
• W2080505830 hasConceptScore W2080505830C207001950 @default.
• W2080505830 hasConceptScore W2080505830C2777516009 @default.
• W2080505830 hasConceptScore W2080505830C2780931953 @default.
• W2080505830 hasConceptScore W2080505830C29730261 @default.
• W2080505830 hasConceptScore W2080505830C71924100 @default.
• W2080505830 hasConceptScore W2080505830C86803240 @default.
• W2080505830 hasConceptScore W2080505830C98274493 @default.
• W2080505830 hasIssue "2" @default.
• W2080505830 hasLocation W20805058301 @default.

• next