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- W2080509124 abstract "The spectrum of proflavine has been examined in the presence of DNA, deoxyribonucleohistone, apurinic acid and sodium poly-l-glutamate. A weak, electrostatic binding process exemplified by the interaction of proflavine with sodium poly-l-glutamate results in a uniform decrease in absorption in the visible range and a slight hypochromism in the ultraviolet region. A strong binding process, involving both electrostatic and Van der Waals forces occurs when proflavine interacts with DNA, heat- or acid-denatured DNA, nucleohistone or apurinic acid. This is characterised by a displacement of the spectrum in the visible range to longer wavelengths and a decrease in absorption in the ultraviolet region. The hypochromism is explained in terms of an interaction between the planar dye molecules and the planar bases on the DNA or apurinic acid and in the case of nucleohistone, between the dye and the bases on the DNA moiety. The binding of proflavine to either DNA or DNH stabilises the macromolecule towards thermal denaturation. The magnitude of the effect depends on the amount of dye bound and reaches an upper limit at low DNA/dye mole ratios which appears to correspond to the upper limit of strong binding. Stabilisation is not observed in solutions of high ionic strength. Theoretical considerations show that the stabilisation is consistent with the intercalation of proflavine molecules between the nucleotide bases of the DNA or deoxyribonucleohistone." @default.
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- W2080509124 date "1965-11-01" @default.
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- W2080509124 title "The effect of proflavine on helix-coil transitions in sodium deoxyribonucleate and deoxyribonucleohistone" @default.
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- W2080509124 doi "https://doi.org/10.1016/0926-6585(65)90185-8" @default.
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