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• W2080512900 abstract "The antilipid peroxidative action of the ethanol extract of Brazilian propolis at a concentration of 47% (w/v) was evaluated by examining the inhibitory effect of the extract on the formation of hydroperoxide- and endoperoxide-type lipid peroxides during heating of authentic polyunsaturated fatty acids and on Fe3+-ADP/ascorbic acid- and Fe3+-ADP/NADPH-dependent lipid peroxidation reactions in rat liver microsomes. Hydroperoxide-type lipid peroxides were measured by the haemoglobin–methylene blue method and endoperoxide-type lipid peroxides by the thiobarbituric aicd (TBA), Fe3+-TBA and LPO-586 methods. Propolis ethanol extract inhibited dose-dependently the formation of hydroperoxide- and endoperoxide-type lipid peroxides during heating of linoleic acid, linolenic acid or arachidonic acid and the amount of the extract causing a half inhibition of these lipid peroxide formations ranged between 20 and 75 μg. Propolis ethanol extract inhibited dose-dependently both Fe3+-ADP/ascorbic acid- and Fe3+-ADP/NADPH-dependent lipid peroxidation reactions in rat liver microsomes when lipid peroxides produced in both reactions were measured by the TBA method. The amount of propolis extract causing a half inhibition of the Fe3+-ADP/ascorbic acid-dependent lipid peroxidation was about 5 μg, while that of the extract causing a half inhibition of the Fe3+-ADP/NADPH-dependent lipid peroxidation was about 0.15 μg. These results indicate that the propolis ethanol extract exerts an antilipid peroxidative action at very low doses. Copyright © 2002 John Wiley & Sons, Ltd." @default.
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• W2080512900 date "2002-01-01" @default.
• W2080512900 modified "2023-10-10" @default.
• W2080512900 title "Evaluation of antilipid peroxidative action of propolis ethanol extract" @default.
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• W2080512900 doi "https://doi.org/10.1002/ptr.894" @default.
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