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- W2080512940 abstract "A condition of maternal thrombophilia, either inherited or acquired, can compromise the success of implantation and foetal survival.Malfunctions in protein C pathway were evaluated using a novel assay [HemosIL ThromboPath (ThP)] in a case-control study of 172 women with a history of recurrent miscarriage or infertility and 86 age-matched unrelated fertile women.Thrombophilia was ascertained in 13% of the cases. ThP values were lower in women either with or without thrombophilia compared to controls (both p<0.0001). Abnormal ThP values (below the mean minus 1SD of controls) were found in 62% of cases compared to 12% of controls (p<0.0001). Non-thrombophilic women who achieved spontaneous pregnancy had higher ThP values compared to those who did not (p<0.05). Elevated ThP values were an independent predictor for pregnancy (p<0.01) in women without thrombophilia. A decrease of ThP values was observed during pregnancy progression, which correlated with that of protein S (p<0.05). Miscarriage or major complications occurred in women in whom ThP percent change was approximately 2-fold higher than that observed in women who achieved successful pregnancy (p<0.05).ThP might represent an efficient assay for screening women with pregnancy complications and might provide prognostic information during pregnancy progression." @default.
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- W2080512940 date "2010-01-01" @default.
- W2080512940 modified "2023-09-27" @default.
- W2080512940 title "Predictive value of thrombopath determination in women with infertility and pregnancy complications" @default.
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- W2080512940 doi "https://doi.org/10.1016/j.cca.2009.09.035" @default.
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