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• W2080513099 abstract "Chronic (5-16 hr) exposure of cultured human lymphocytes to 10 -8 M insulin at 37° in vitro produced a decrease in insulin receptor concentrations unaccounted for by simple occupancy of sites; acute exposure (0-2 hr) was without effect. These results reproduced observations in vivo where chronic hyperinsulinemia (e.g., 10 -8 M insulin in the circulation of obese insulinresistant hyperglycemic mice) is associated with a substantial reduction in the concentration of insulin receptors per cell, while acute hyperinsulinemia in vivo has no effect on receptor concentration. These data suggest a reciprocal relationship between insulin in the extracellular fluid and the concentration of insulin receptors per cell, which is mediated at the target cell itself by intracellular insulin-sensitive regulatory processes and directly affects target-cell sensitivity to hormone." @default.
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• W2080513099 date "1974-01-01" @default.
• W2080513099 modified "2023-10-16" @default.
• W2080513099 title "Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture" @default.
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• W2080513099 doi "https://doi.org/10.1073/pnas.71.1.84" @default.
• W2080513099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/387937" @default.
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