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- W2080521516 abstract "It is demonstrated that mixed-sequence phosphorothioate oligodeoxyribonucleotides can be synthesized on scales from 1 μmol up to 80 mmol without using chlorinated solvents such as dichloromethane or dichloroethane, while preserving both high yield and purity of the product. A solution of dichloroacetic acid in organic solvents (e.g., toluene, xylenes, benzotrifluoride) cleanly and efficiently removes the 4,4‘-dimethoxytrityl (DMTr) group from the 5‘-terminus of the growing oligonucleotide chain during synthesis on solid support. We have therefore replaced hazardous dichloromethane, formerly used in oligonucleotide synthesis, as the solvent for DMTr-removal, with toluene." @default.
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- W2080521516 date "1999-12-23" @default.
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- W2080521516 title "Large-Scale Synthesis of Antisense Oligonucleotides without Chlorinated Solvents" @default.
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- W2080521516 doi "https://doi.org/10.1021/op990183d" @default.
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