Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080523215> ?p ?o ?g. }
- W2080523215 endingPage "28930" @default.
- W2080523215 startingPage "28921" @default.
- W2080523215 abstract "Histone deacetylase-2 (HDAC2) is a component of a complex that mediates transcriptional repression in mammalian cells. A mouse HDAC2 cDNA was used to identify several recombinant clones containing the entire mouse HDAC2 gene. The mouse HDAC2 gene spans over 36 kilobase pairs and is composed of 14 exons (ranging from 58 to 362 nucleotides in length) and 13 introns (ranging from 75 base pairs to 19 kilobase pairs in length). Primer extension analysis with total RNA from NIH3T3 cells revealed a major transcriptional start site at 221 base pairs 5' of the ATG translational start codon. Upstream of the transcriptional start site, no canonical TATA box was found, but binding sites for several known transcription factors were identified. Transient transfection studies with 5' deletion mutants localized the promoter to no more than 76 base pairs upstream from the major transcriptional start site. Fluorescence in situ hybridization mapped mouse HDAC2 to chromosomal location 10B1, which is in close proximity to the growth factor-inducible gene fisp-12. Information concerning the genomic organization and promoter of HDAC2 will be useful in studies of the regulation of histone deacetylase activities, which in turn are important in studies of the regulation of transcriptional repression in mammalian cells." @default.
- W2080523215 created "2016-06-24" @default.
- W2080523215 creator A5004256523 @default.
- W2080523215 creator A5010411205 @default.
- W2080523215 creator A5048365788 @default.
- W2080523215 creator A5070092909 @default.
- W2080523215 creator A5071411150 @default.
- W2080523215 date "1998-11-01" @default.
- W2080523215 modified "2023-09-30" @default.
- W2080523215 title "Cloning and Characterization of the Mouse Histone Deacetylase-2 Gene" @default.
- W2080523215 cites W1486257535 @default.
- W2080523215 cites W1486948598 @default.
- W2080523215 cites W1500049606 @default.
- W2080523215 cites W1542568976 @default.
- W2080523215 cites W1550565578 @default.
- W2080523215 cites W1608386720 @default.
- W2080523215 cites W1635667563 @default.
- W2080523215 cites W1646199134 @default.
- W2080523215 cites W1665024321 @default.
- W2080523215 cites W1784857457 @default.
- W2080523215 cites W1947449479 @default.
- W2080523215 cites W1963573390 @default.
- W2080523215 cites W1965372133 @default.
- W2080523215 cites W1968112541 @default.
- W2080523215 cites W1974112332 @default.
- W2080523215 cites W1978921101 @default.
- W2080523215 cites W1980483123 @default.
- W2080523215 cites W1981022538 @default.
- W2080523215 cites W1985063313 @default.
- W2080523215 cites W1988734689 @default.
- W2080523215 cites W1993243592 @default.
- W2080523215 cites W1996749102 @default.
- W2080523215 cites W1999952815 @default.
- W2080523215 cites W2003959153 @default.
- W2080523215 cites W2004988279 @default.
- W2080523215 cites W2010049199 @default.
- W2080523215 cites W2013812530 @default.
- W2080523215 cites W2016567695 @default.
- W2080523215 cites W2017867661 @default.
- W2080523215 cites W2024018102 @default.
- W2080523215 cites W2025438239 @default.
- W2080523215 cites W2026441085 @default.
- W2080523215 cites W2034331383 @default.
- W2080523215 cites W2036639816 @default.
- W2080523215 cites W2040193953 @default.
- W2080523215 cites W2042315437 @default.
- W2080523215 cites W2042777921 @default.
- W2080523215 cites W2052357638 @default.
- W2080523215 cites W2060696024 @default.
- W2080523215 cites W2062414406 @default.
- W2080523215 cites W2063460322 @default.
- W2080523215 cites W2067388503 @default.
- W2080523215 cites W2071981322 @default.
- W2080523215 cites W2074096799 @default.
- W2080523215 cites W2075260456 @default.
- W2080523215 cites W2086132387 @default.
- W2080523215 cites W2086778920 @default.
- W2080523215 cites W2088577765 @default.
- W2080523215 cites W2088665501 @default.
- W2080523215 cites W2095115211 @default.
- W2080523215 cites W2095217266 @default.
- W2080523215 cites W2104788426 @default.
- W2080523215 cites W2112365969 @default.
- W2080523215 cites W2113261653 @default.
- W2080523215 cites W2118862408 @default.
- W2080523215 cites W2138270253 @default.
- W2080523215 cites W2154939249 @default.
- W2080523215 cites W4236512674 @default.
- W2080523215 cites W4294216491 @default.
- W2080523215 doi "https://doi.org/10.1074/jbc.273.44.28921" @default.
- W2080523215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9786895" @default.
- W2080523215 hasPublicationYear "1998" @default.
- W2080523215 type Work @default.
- W2080523215 sameAs 2080523215 @default.
- W2080523215 citedByCount "25" @default.
- W2080523215 countsByYear W20805232152013 @default.
- W2080523215 countsByYear W20805232152014 @default.
- W2080523215 countsByYear W20805232152016 @default.
- W2080523215 countsByYear W20805232152018 @default.
- W2080523215 countsByYear W20805232152020 @default.
- W2080523215 countsByYear W20805232152021 @default.
- W2080523215 crossrefType "journal-article" @default.
- W2080523215 hasAuthorship W2080523215A5004256523 @default.
- W2080523215 hasAuthorship W2080523215A5010411205 @default.
- W2080523215 hasAuthorship W2080523215A5048365788 @default.
- W2080523215 hasAuthorship W2080523215A5070092909 @default.
- W2080523215 hasAuthorship W2080523215A5071411150 @default.
- W2080523215 hasBestOaLocation W20805232151 @default.
- W2080523215 hasConcept C104317684 @default.
- W2080523215 hasConcept C121050878 @default.
- W2080523215 hasConcept C153911025 @default.
- W2080523215 hasConcept C199360897 @default.
- W2080523215 hasConcept C27253355 @default.
- W2080523215 hasConcept C2778305200 @default.
- W2080523215 hasConcept C41008148 @default.
- W2080523215 hasConcept C4951695 @default.
- W2080523215 hasConcept C54355233 @default.
- W2080523215 hasConcept C64927066 @default.