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• W2080525095 abstract "Background: Hepatocyte growth factor (HGF) is a multifunctional cytokine that is involved in recovery process after organ injuries. Objective: We studied HGF and the membrane bound receptor, c-met locally in patients who suffered from chronic leg ulcers (≥1 year) caused by venous insufficiency. Methods: Skin biopsies from the edge of the ulcers were taken from patients (n = 13) and studied by immunohistochemical staining for detection of HGF and c-met. Skin biopsies from healthy volunteers (n = 10) were used as the control material. Ulcer secretion from chronic ulcers (n = 11) was examined for the presence of HGF by ELISA and the concentration of HGF was compared with acute ulcers in healthy controls (n = 10) and in patients operated for a non-invasive breast cancer (n = 12). Results: We observed that c-met expression in the ulcer area increased significantly in chronic ulcers compared to controls (p = 0.005). Concentration of ulcer-HGF in the patients with chronic ulcer was significantly higher than acute ulcers (p < 0.01). The biological activity of HGF in ulcer secret was assessed in-vitro in transferred, mouse skin epithelial cell monolayer. Enhanced migration and morphologic changes were seen after adding ulcer secret from acute ulcers (>1 ng/mL) that was inhibited by anti-HGF antibodies. No biological activity was observed by adding ulcer secret from chronic ulcers irrespective HGF concentration. Conclusion: We conclude that in chronic skin ulcers decreased biological activity of endogenous HGF and overexpression of c-met is seen which might explain fibrosis and delayed recovery. Administration of exogenous active HGF might contribute to accelerated healing in these patients." @default.
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• W2080525095 date "2005-02-01" @default.
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• W2080525095 title "Hepatocyte growth factor; expression, concentration and biological activity in chronic leg ulcers" @default.
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• W2080525095 doi "https://doi.org/10.1016/j.jdermsci.2004.11.002" @default.
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