FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080542488> ?p ?o ?g. }

• W2080542488 endingPage "12993" @default.
• W2080542488 startingPage "12990" @default.
• W2080542488 abstract "Presynaptic injection of inositol 1,3,4,5-tetraphosphate, inositol 1,3,4,5,6-pentakisphosphate, or inositol 1,2,3,4,5,6-hexakisphosphate--which we denote here the inositol high-polyphosphate series (IHPS)--is shown to block synaptic transmission when injected into the preterminal of the squid giant synapse. This effect is not produced by injection of inositol 1,4,5-trisphosphate. The synaptic block is characterized by a time course in the order of 15-45 min, depending on the injection site in the preterminal fiber; the fastest block occurs when the injection is made at the terminal release site. Presynaptic voltage clamp during transmitter release demonstrates that IHPS block did not modify the presynaptic inward, calcium current. Analysis of synaptic noise at the postsynaptic axon shows that both the evoked and spontaneous transmitter release are blocked by the IHPS. Tetanic stimulation of the presynaptic fiber at frequencies of 100 Hz indicates that block is accompanied by gradual reduction of the postsynaptic response, demonstrating that the block interferes with vesicular fusion rather than with vesicular docking. These results, in combination with the recently demonstrated observation that the IHPS bind the C2B domain in synaptotagmin [Fukada, M., Aruga, J., Niinobe, M., Aimoto, S. & Mikoshiba, K. (1994) J. Biol. Chem. 269, 29206-29211], suggest that IHPS elements are involved in vesicle fusion and exocytosis. In addition, a scheme is proposed in which synaptotagmin triggers transmitter release directly by promoting the fusion of synaptic vesicles with the presynaptic plasmalemma, in agreement with the very rapid nature of transmitter release in chemical synapses." @default.
• W2080542488 created "2016-06-24" @default.
• W2080542488 creator A5006129467 @default.
• W2080542488 creator A5010754920 @default.
• W2080542488 creator A5035555934 @default.
• W2080542488 creator A5040658791 @default.
• W2080542488 creator A5048463873 @default.
• W2080542488 creator A5058506822 @default.
• W2080542488 creator A5070542812 @default.
• W2080542488 date "1994-12-20" @default.
• W2080542488 modified "2023-10-15" @default.
• W2080542488 title "The inositol high-polyphosphate series blocks synaptic transmission by preventing vesicular fusion: a squid giant synapse study." @default.
• W2080542488 cites W1541505552 @default.
• W2080542488 cites W1544609822 @default.
• W2080542488 cites W1568294354 @default.
• W2080542488 cites W1591133722 @default.
• W2080542488 cites W1963783599 @default.
• W2080542488 cites W1977300648 @default.
• W2080542488 cites W1988652098 @default.
• W2080542488 cites W2013907969 @default.
• W2080542488 cites W2021788635 @default.
• W2080542488 cites W2032562864 @default.
• W2080542488 cites W2035347592 @default.
• W2080542488 cites W2075183645 @default.
• W2080542488 cites W2129090701 @default.
• W2080542488 cites W2129696839 @default.
• W2080542488 doi "https://doi.org/10.1073/pnas.91.26.12990" @default.
• W2080542488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/45566" @default.
• W2080542488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7809161" @default.
• W2080542488 hasPublicationYear "1994" @default.
• W2080542488 type Work @default.
• W2080542488 sameAs 2080542488 @default.
• W2080542488 citedByCount "88" @default.
• W2080542488 countsByYear W20805424882012 @default.
• W2080542488 countsByYear W20805424882013 @default.
• W2080542488 countsByYear W20805424882014 @default.
• W2080542488 countsByYear W20805424882016 @default.
• W2080542488 countsByYear W20805424882019 @default.
• W2080542488 countsByYear W20805424882020 @default.
• W2080542488 countsByYear W20805424882022 @default.
• W2080542488 countsByYear W20805424882023 @default.
• W2080542488 crossrefType "journal-article" @default.
• W2080542488 hasAuthorship W2080542488A5006129467 @default.
• W2080542488 hasAuthorship W2080542488A5010754920 @default.
• W2080542488 hasAuthorship W2080542488A5035555934 @default.
• W2080542488 hasAuthorship W2080542488A5040658791 @default.
• W2080542488 hasAuthorship W2080542488A5048463873 @default.
• W2080542488 hasAuthorship W2080542488A5058506822 @default.
• W2080542488 hasAuthorship W2080542488A5070542812 @default.
• W2080542488 hasBestOaLocation W20805424882 @default.
• W2080542488 hasConcept C12554922 @default.
• W2080542488 hasConcept C127445978 @default.
• W2080542488 hasConcept C130316041 @default.
• W2080542488 hasConcept C148785051 @default.
• W2080542488 hasConcept C169760540 @default.
• W2080542488 hasConcept C170493617 @default.
• W2080542488 hasConcept C185592680 @default.
• W2080542488 hasConcept C197341189 @default.
• W2080542488 hasConcept C200170125 @default.
• W2080542488 hasConcept C2777427919 @default.
• W2080542488 hasConcept C41625074 @default.
• W2080542488 hasConcept C55493867 @default.
• W2080542488 hasConcept C86803240 @default.
• W2080542488 hasConcept C95444343 @default.
• W2080542488 hasConceptScore W2080542488C12554922 @default.
• W2080542488 hasConceptScore W2080542488C127445978 @default.
• W2080542488 hasConceptScore W2080542488C130316041 @default.
• W2080542488 hasConceptScore W2080542488C148785051 @default.
• W2080542488 hasConceptScore W2080542488C169760540 @default.
• W2080542488 hasConceptScore W2080542488C170493617 @default.
• W2080542488 hasConceptScore W2080542488C185592680 @default.
• W2080542488 hasConceptScore W2080542488C197341189 @default.
• W2080542488 hasConceptScore W2080542488C200170125 @default.
• W2080542488 hasConceptScore W2080542488C2777427919 @default.
• W2080542488 hasConceptScore W2080542488C41625074 @default.
• W2080542488 hasConceptScore W2080542488C55493867 @default.
• W2080542488 hasConceptScore W2080542488C86803240 @default.
• W2080542488 hasConceptScore W2080542488C95444343 @default.
• W2080542488 hasIssue "26" @default.
• W2080542488 hasLocation W20805424881 @default.
• W2080542488 hasLocation W20805424882 @default.
• W2080542488 hasLocation W20805424883 @default.
• W2080542488 hasLocation W20805424884 @default.
• W2080542488 hasOpenAccess W2080542488 @default.
• W2080542488 hasPrimaryLocation W20805424881 @default.
• W2080542488 hasRelatedWork W1524071937 @default.
• W2080542488 hasRelatedWork W1595326866 @default.
• W2080542488 hasRelatedWork W2001299366 @default.
• W2080542488 hasRelatedWork W2021431294 @default.
• W2080542488 hasRelatedWork W2060449557 @default.
• W2080542488 hasRelatedWork W2074830850 @default.
• W2080542488 hasRelatedWork W2090428859 @default.
• W2080542488 hasRelatedWork W2358740485 @default.
• W2080542488 hasRelatedWork W2986266581 @default.
• W2080542488 hasRelatedWork W2274977358 @default.
• W2080542488 hasVolume "91" @default.
• W2080542488 isParatext "false" @default.
• W2080542488 isRetracted "false" @default.

• next