Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080542886> ?p ?o ?g. }
- W2080542886 endingPage "580" @default.
- W2080542886 startingPage "565" @default.
- W2080542886 abstract "Non-alcoholic fatty liver disease (NAFLD) results from increased hepatic lipid accumulation and steatosis, and is closely linked to liver one-carbon (C1) metabolism. We assessed in C57BL6/N mice whether NAFLD induced by a high-fat (HF) diet over 8 weeks can be reversed by additional 4 weeks of a dietary methyl-donor supplementation (MDS). MDS in the obese mice failed to reverse NAFLD, but prevented the progression of hepatic steatosis associated with major changes in key hepatic C1-metabolites, e.g. S-adenosyl-methionine and S-adenosyl-homocysteine. Increased phosphorylation of AMPK-α together with enhanced β-HAD activity suggested an increased flux through fatty acid oxidation pathways. This was supported by concomitantly decreased hepatic free fatty acid and acyl-carnitines levels. Although HF diet changed the hepatic phospholipid pattern, MDS did not. Our findings suggest that dietary methyl-donors activate AMPK, a key enzyme in fatty acid β-oxidation control, that mediates increased fatty acid utilization and thereby prevents further hepatic lipid accumulation." @default.
- W2080542886 created "2016-06-24" @default.
- W2080542886 creator A5014662738 @default.
- W2080542886 creator A5016616599 @default.
- W2080542886 creator A5023429626 @default.
- W2080542886 creator A5023519695 @default.
- W2080542886 creator A5027362715 @default.
- W2080542886 creator A5052254284 @default.
- W2080542886 creator A5054720911 @default.
- W2080542886 creator A5057449920 @default.
- W2080542886 creator A5058610557 @default.
- W2080542886 creator A5067551418 @default.
- W2080542886 creator A5080085846 @default.
- W2080542886 date "2014-08-01" @default.
- W2080542886 modified "2023-10-01" @default.
- W2080542886 title "Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels" @default.
- W2080542886 cites W1527275481 @default.
- W2080542886 cites W1657478053 @default.
- W2080542886 cites W1763805809 @default.
- W2080542886 cites W1963756943 @default.
- W2080542886 cites W1964410776 @default.
- W2080542886 cites W1978763812 @default.
- W2080542886 cites W1983336199 @default.
- W2080542886 cites W1988826453 @default.
- W2080542886 cites W1993168177 @default.
- W2080542886 cites W1993170631 @default.
- W2080542886 cites W1995567920 @default.
- W2080542886 cites W2001940599 @default.
- W2080542886 cites W2002613261 @default.
- W2080542886 cites W2004345371 @default.
- W2080542886 cites W2004842870 @default.
- W2080542886 cites W2008169198 @default.
- W2080542886 cites W2013635918 @default.
- W2080542886 cites W2016752484 @default.
- W2080542886 cites W2023952336 @default.
- W2080542886 cites W2026342971 @default.
- W2080542886 cites W2032878070 @default.
- W2080542886 cites W2033957878 @default.
- W2080542886 cites W2040109162 @default.
- W2080542886 cites W2042706232 @default.
- W2080542886 cites W2053026149 @default.
- W2080542886 cites W2054601149 @default.
- W2080542886 cites W2067669340 @default.
- W2080542886 cites W2071457248 @default.
- W2080542886 cites W2073086944 @default.
- W2080542886 cites W2077645437 @default.
- W2080542886 cites W2078410199 @default.
- W2080542886 cites W2080049485 @default.
- W2080542886 cites W2083625204 @default.
- W2080542886 cites W2083754466 @default.
- W2080542886 cites W2085170886 @default.
- W2080542886 cites W2089401171 @default.
- W2080542886 cites W2089533237 @default.
- W2080542886 cites W2099824652 @default.
- W2080542886 cites W2107277218 @default.
- W2080542886 cites W2112523812 @default.
- W2080542886 cites W2114825802 @default.
- W2080542886 cites W2118001240 @default.
- W2080542886 cites W2122500634 @default.
- W2080542886 cites W2127281349 @default.
- W2080542886 cites W2127659234 @default.
- W2080542886 cites W2132346675 @default.
- W2080542886 cites W2134345362 @default.
- W2080542886 cites W2134823147 @default.
- W2080542886 cites W2136725787 @default.
- W2080542886 cites W2136795008 @default.
- W2080542886 cites W2142540919 @default.
- W2080542886 cites W2143537504 @default.
- W2080542886 cites W2144211804 @default.
- W2080542886 cites W2148245420 @default.
- W2080542886 cites W2156875759 @default.
- W2080542886 cites W2169288108 @default.
- W2080542886 cites W2169761177 @default.
- W2080542886 cites W4230280576 @default.
- W2080542886 cites W4290960820 @default.
- W2080542886 cites W69397147 @default.
- W2080542886 doi "https://doi.org/10.1016/j.molmet.2014.04.010" @default.
- W2080542886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4099513" @default.
- W2080542886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25061561" @default.
- W2080542886 hasPublicationYear "2014" @default.
- W2080542886 type Work @default.
- W2080542886 sameAs 2080542886 @default.
- W2080542886 citedByCount "85" @default.
- W2080542886 countsByYear W20805428862014 @default.
- W2080542886 countsByYear W20805428862015 @default.
- W2080542886 countsByYear W20805428862016 @default.
- W2080542886 countsByYear W20805428862017 @default.
- W2080542886 countsByYear W20805428862018 @default.
- W2080542886 countsByYear W20805428862019 @default.
- W2080542886 countsByYear W20805428862020 @default.
- W2080542886 countsByYear W20805428862021 @default.
- W2080542886 countsByYear W20805428862022 @default.
- W2080542886 countsByYear W20805428862023 @default.
- W2080542886 crossrefType "journal-article" @default.
- W2080542886 hasAuthorship W2080542886A5014662738 @default.
- W2080542886 hasAuthorship W2080542886A5016616599 @default.
- W2080542886 hasAuthorship W2080542886A5023429626 @default.
- W2080542886 hasAuthorship W2080542886A5023519695 @default.