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- W2080545586 abstract "Abstract Fifteen to 20% of patients of all ages treated with anti-infectious drugs report symptoms suggestive of a hypersensitivity reaction, most often related to a betalactam. Allergy studies show that most reactions to betalactams reported in children do not result from anti-microbial drug hypersensitivity. Nevertheless, the risk of hypersensitivity to these drugs is high in children who have previously had anaphylaxis, immediate urticaria and/or angioedema. Following an initial medical history, skin tests with betalactams are the next diagnostic step. Immediate skin tests to betalactams have been standardized and have good diagnostic and predictive values, whereas the predictive value of in vitro tests for immediate and non-immediate hypersensitivity to betalactams has not been proven. Immediate skin tests are indicated mainly in patients reporting reactions suggestive of immediate hypersensitivity, and they provide confirmation or rejection of a diagnosis of sensitization to betalactams and at the same time provide evidence for sensitization to one or more betalactams of the same and/or different class. Except for patch tests (for eczema) and photopatch-tests (for photodermatoses), the predictive values of delayed skin tests to anti-microbial drugs remain uncertain, and a large proportion of such delayed reactions must be diagnosed by challenge tests. Note that challenge tests are strictly contraindicated in children reporting symptoms suggestive of (pseudo-) serum sickness or a (potentially) severe toxic epidermal necrolysis (TEN) reaction." @default.
- W2080545586 created "2016-06-24" @default.
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- W2080545586 date "2003-06-01" @default.
- W2080545586 modified "2023-09-26" @default.
- W2080545586 title "Allergic and pseudoallergic reactions to betalactam antibiotics in children" @default.
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- W2080545586 doi "https://doi.org/10.1016/s0335-7457(03)00101-1" @default.
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