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• W2080546926 endingPage "125" @default.
• W2080546926 startingPage "118" @default.
• W2080546926 abstract "Dietary flavonoids possess a multiplicity of neuroprotective actions in various central nervous pathophysiological conditions including depression. Ellagic acid is a polyphenolic compound that occurs in plants such as raspberries, nuts and eucalyptus species. The present study was designed to investigate the antidepressant-like effect of ellagic acid in mice using forced swimming test (FST) and tail suspension test (TST). The involvement of the monoaminergic and opioid systems in the antidepressant-like activity of ellagic acid was also studied. Our results showed that ellagic acid when administered acutely or chronically to mice (25, 50 and 100 mg/kg, p.o.), produced a significant reduction in the duration of immobility, with a profile comparable to that of fluoxetine (20 mg/kg, p.o.). However, ellagic acid treatment had no effect on the locomotor activity of mice when tested in actophotometer. The reduction in immobility time observed with ellagic acid treatment (50 mg/kg, p.o.) was prevented by pretreatment with p-chlorophenylalanine (100 mg/kg, i.p., a serotonin synthesis inhibitor), pindolol (10 mg/kg, i.p., a β-adrenoceptors blocker/5HT1A/1B receptor antagonist), ketanserin (5 mg/kg, i.p., a 5HT2A/2B receptor antagonist), ondansetron (1 mg/kg, i.p., a 5HT3 receptor antagonist), prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist) and yohimbine (1 mg/kg, i.p., an α2-adrenoceptor antagonist), but not with naloxone (1 mg/kg, i.p., an opioid receptor antagonist). Our results suggest that ellagic acid produced an antidepressant-like effect which was unrelated to its locomotor activity. Furthermore, this anti-immobility effect seems most likely to be mediated through an interaction with the monoaminergic system (serotonergic and noradrenergic systems) and not through the opioid system." @default.
• W2080546926 created "2016-06-24" @default.
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• W2080546926 date "2012-05-01" @default.
• W2080546926 modified "2023-10-01" @default.
• W2080546926 title "Evidence for the involvement of the monoaminergic system, but not the opioid system in the antidepressant-like activity of ellagic acid in mice" @default.
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• W2080546926 doi "https://doi.org/10.1016/j.ejphar.2012.02.034" @default.
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