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- W2080550908 abstract "Halogen-substituted quinolines have been synthesized in good yields by the condensation and cyclization of two molecules of ortho-haloacetophenones with urea or primary amines. The formation of halogen-substituted quinolines takes place through the unexpected catalyst-free cleavage of C(sp2)–X (X=Cl, Br), α-C(sp3)–H bonds and formation of C–C, C–N bonds in a selective manner. The attractive features of the present synthetic method for halogen-substituted quinolines include catalyst-free, one-pot process, easy availability of starting materials, and introduction of halogen on the quinoline ring for further transformation." @default.
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- W2080550908 date "2009-02-01" @default.
- W2080550908 modified "2023-09-24" @default.
- W2080550908 title "A domino three-component condensation of ortho-haloacetophenones with urea or amines: a novel one-pot synthesis of halogen-substituted quinolines" @default.
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- W2080550908 doi "https://doi.org/10.1016/j.tet.2008.12.039" @default.
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