FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080551431> ?p ?o ?g. }

• W2080551431 endingPage "233" @default.
• W2080551431 startingPage "225" @default.
• W2080551431 abstract "Background: Resistance commonly arises in infants exposed to single-dose nevirapine (sdNVP) for prevention of mother to child transmission. Although K103N and Y181C are common following sdNVP, multiple other mutations also confer NVP resistance. It remains unclear whether specific NVP resistance mutations or combinations of mutations predict virologic failure in infants when present at low frequencies before NVP-based treatment. Methods: Twenty sdNVP-exposed infants who were subsequently treated with NVP-based highly active antiretroviral therapy were examined. Pretreatment plasma samples were tested for the presence of NVP resistance mutations by allele-specific polymerase chain reaction for K103N and Y181C and ultradeep pyrosequencing (UDPS) for all primary NVP mutations. Viral levels were determined every 3 months for up to 24 months on NVP–highly active antiretroviral therapy. Cox proportional hazard models were used to determine correlates of viral failure. Results: The NVP resistance mutations K103N or Y181C were detected in pretreatment plasma samples in 6 infants by allele-specific polymerase chain reaction. NVP resistance at these or other sites was detectable by UDPS in 10 of 20 infants tested. Virologic failure occurred in 50% of infants with any NVP resistance mutations detected, whereas only 20% of infants without resistance experienced viral failure, but the difference was not significant (P = 0.19). An increase in the number of NVP resistance mutations detectable by UDPS in an infant was significantly associated with an increased risk of virologic failure [HR = 1.79 (95% confidence interval: 1.07 to 2.99), P = 0.027]. Conclusions: Low frequencies of multiple NVP resistance mutations, in addition to K103N and Y181C, present in infants before NVP-based treatment may predict treatment outcome." @default.
• W2080551431 created "2016-06-24" @default.
• W2080551431 creator A5005104278 @default.
• W2080551431 creator A5007081009 @default.
• W2080551431 creator A5017200319 @default.
• W2080551431 creator A5042236106 @default.
• W2080551431 creator A5048323364 @default.
• W2080551431 creator A5059164563 @default.
• W2080551431 creator A5061366174 @default.
• W2080551431 creator A5066575948 @default.
• W2080551431 creator A5074561782 @default.
• W2080551431 creator A5075328638 @default.
• W2080551431 creator A5084752404 @default.
• W2080551431 date "2012-07-01" @default.
• W2080551431 modified "2023-10-02" @default.
• W2080551431 title "Low-Frequency Nevirapine Resistance at Multiple Sites May Predict Treatment Failure in Infants on Nevirapine-Based Treatment" @default.
• W2080551431 cites W1812611692 @default.
• W2080551431 cites W1965163484 @default.
• W2080551431 cites W1969073576 @default.
• W2080551431 cites W1982652851 @default.
• W2080551431 cites W1987858510 @default.
• W2080551431 cites W1990105675 @default.
• W2080551431 cites W1994630094 @default.
• W2080551431 cites W1996423252 @default.
• W2080551431 cites W2005206478 @default.
• W2080551431 cites W2014366116 @default.
• W2080551431 cites W2034321261 @default.
• W2080551431 cites W2042148102 @default.
• W2080551431 cites W2058671354 @default.
• W2080551431 cites W2077956544 @default.
• W2080551431 cites W2081745197 @default.
• W2080551431 cites W2088020479 @default.
• W2080551431 cites W2089289885 @default.
• W2080551431 cites W2089596992 @default.
• W2080551431 cites W2094340292 @default.
• W2080551431 cites W2104966707 @default.
• W2080551431 cites W2106089827 @default.
• W2080551431 cites W2115763450 @default.
• W2080551431 cites W2118435139 @default.
• W2080551431 cites W2132050166 @default.
• W2080551431 cites W2134746895 @default.
• W2080551431 cites W2138106725 @default.
• W2080551431 cites W2139311359 @default.
• W2080551431 cites W2145030314 @default.
• W2080551431 cites W2147072996 @default.
• W2080551431 cites W2148521133 @default.
• W2080551431 cites W2148684707 @default.
• W2080551431 cites W2170947401 @default.
• W2080551431 doi "https://doi.org/10.1097/qai.0b013e3182515730" @default.
• W2080551431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3383885" @default.
• W2080551431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22395670" @default.
• W2080551431 hasPublicationYear "2012" @default.
• W2080551431 type Work @default.
• W2080551431 sameAs 2080551431 @default.
• W2080551431 citedByCount "36" @default.
• W2080551431 countsByYear W20805514312013 @default.
• W2080551431 countsByYear W20805514312014 @default.
• W2080551431 countsByYear W20805514312015 @default.
• W2080551431 countsByYear W20805514312016 @default.
• W2080551431 countsByYear W20805514312017 @default.
• W2080551431 countsByYear W20805514312018 @default.
• W2080551431 countsByYear W20805514312019 @default.
• W2080551431 countsByYear W20805514312020 @default.
• W2080551431 countsByYear W20805514312021 @default.
• W2080551431 countsByYear W20805514312022 @default.
• W2080551431 countsByYear W20805514312023 @default.
• W2080551431 crossrefType "journal-article" @default.
• W2080551431 hasAuthorship W2080551431A5005104278 @default.
• W2080551431 hasAuthorship W2080551431A5007081009 @default.
• W2080551431 hasAuthorship W2080551431A5017200319 @default.
• W2080551431 hasAuthorship W2080551431A5042236106 @default.
• W2080551431 hasAuthorship W2080551431A5048323364 @default.
• W2080551431 hasAuthorship W2080551431A5059164563 @default.
• W2080551431 hasAuthorship W2080551431A5061366174 @default.
• W2080551431 hasAuthorship W2080551431A5066575948 @default.
• W2080551431 hasAuthorship W2080551431A5074561782 @default.
• W2080551431 hasAuthorship W2080551431A5075328638 @default.
• W2080551431 hasAuthorship W2080551431A5084752404 @default.
• W2080551431 hasBestOaLocation W20805514311 @default.
• W2080551431 hasConcept C104317684 @default.
• W2080551431 hasConcept C114851261 @default.
• W2080551431 hasConcept C126322002 @default.
• W2080551431 hasConcept C142462285 @default.
• W2080551431 hasConcept C159047783 @default.
• W2080551431 hasConcept C180754005 @default.
• W2080551431 hasConcept C2779130552 @default.
• W2080551431 hasConcept C2993143319 @default.
• W2080551431 hasConcept C3013748606 @default.
• W2080551431 hasConcept C44249647 @default.
• W2080551431 hasConcept C48126324 @default.
• W2080551431 hasConcept C49105822 @default.
• W2080551431 hasConcept C54355233 @default.
• W2080551431 hasConcept C71924100 @default.
• W2080551431 hasConcept C86803240 @default.
• W2080551431 hasConcept C89423630 @default.
• W2080551431 hasConceptScore W2080551431C104317684 @default.
• W2080551431 hasConceptScore W2080551431C114851261 @default.
• W2080551431 hasConceptScore W2080551431C126322002 @default.

• next