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- W2080554496 abstract "Abstract Electron microscopic analysis of heteroduplexes formed between genomic RNA of Friend spleen focus-forming virus (F-SFFV) and long complementary DNA (cDNA) transcripts obtained from either Friend or Moloney murine leukemia virus were characterized by three major deletions and a major and minor substitution. Starting from the 3′-end of the genome, the three deletion loops extend 0.91 to 1.50 kilobases (kb) (deletion loop 1), 3.34 to 4.08 kb (deletion loop 2), and 4.82 to 5.50 kb (deletion loop 3). The major substitution loop A extends from 1.73 to 2.53 kb and the minor substitution loop B is located between 6 and 7 kb from the 3′-end of the genome. Heteroduplexes formed between BALB-virus 2 cDNA transcripts and F-SFFV RNA showed the three deletion loops but not the major substitution loop A. We conclude that sequences present in the substitution loop A are homologous to BALB-virus 2 sequences. Furthermore, the F-SFFV genome has incurred deletions in the env and the pol gene regions and has undergone sequence substitutions within the env and gag genes." @default.
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- W2080554496 date "1980-04-01" @default.
- W2080554496 modified "2023-09-23" @default.
- W2080554496 title "Genome organization of retroviruses IX. Analysis of the genomes of friend spleen focus-forming (F-SFFV) and helper murine leukemia viruses by heteroduplex-formation" @default.
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- W2080554496 doi "https://doi.org/10.1016/0042-6822(80)90088-4" @default.
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