FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080557402> ?p ?o ?g. }

• W2080557402 endingPage "872" @default.
• W2080557402 startingPage "869" @default.
• W2080557402 abstract "Alterations in brain density and signaling associated with monoamine receptors are believed to play a role in depressive disorders. This study evaluates the functional status of α₂(A)-adrenoceptors in postmortem frontal cortex of depressed subjects.G-protein activation and inhibition of adenylyl cyclase (AC) activity induced by the α₂-adrenoceptor agonist UK14304 were measured in triplicate in samples from 15 suicide victims with an antemortem diagnosis of major depression and 15 matched control subjects.Basal [³⁵S] guanosine γ thio-phosphate (GTPγS) binding and cyclic adenosine monophosphate accumulation did not differ between groups. In depressed victims, an increase in [³⁵S] GTPγS binding potency (EC₅₀ = .58 μmol/L vs. EC₅₀ = 3.31 μmol/L; p < .01; depressed vs. control) and a significant reduction in the maximal inhibition of AC activity (I(max) = 27 ± 4% vs. I(max) = 47 ± 5%; p < .01) were observed after incubation with the α(2)-adrenoceptor agonist UK14304. No differences were found between antidepressant-free and antidepressant-treated subjects. A significant relationship between EC₅₀ values for [³⁵S] GTPγS and I(max) values for AC assay was found (n = 30; r = -.43; p < .05).The dual regulation of α(2A)-adrenoceptor signaling pathways raises the possibility that factors affecting the G-protein cycle and/or selective access of Gα(i/o)-protein to AC might be relevant to receptor abnormalities in depression, providing further support for the involvement of α₂(A)-adrenoceptors in the pathogenesis of depression." @default.
• W2080557402 created "2016-06-24" @default.
• W2080557402 creator A5002190224 @default.
• W2080557402 creator A5024198476 @default.
• W2080557402 creator A5044317538 @default.
• W2080557402 creator A5047587284 @default.
• W2080557402 creator A5063642220 @default.
• W2080557402 creator A5073705350 @default.
• W2080557402 creator A5083352205 @default.
• W2080557402 date "2010-11-01" @default.
• W2080557402 modified "2023-10-18" @default.
• W2080557402 title "α2-Adrenoceptor Functionality in Postmortem Frontal Cortex of Depressed Suicide Victims" @default.
• W2080557402 cites W1967437665 @default.
• W2080557402 cites W1974195176 @default.
• W2080557402 cites W1983463028 @default.
• W2080557402 cites W1985254179 @default.
• W2080557402 cites W1985590541 @default.
• W2080557402 cites W2025682675 @default.
• W2080557402 cites W2026657801 @default.
• W2080557402 cites W2042421949 @default.
• W2080557402 cites W2044479691 @default.
• W2080557402 cites W2056502744 @default.
• W2080557402 cites W2058245744 @default.
• W2080557402 cites W2062634104 @default.
• W2080557402 cites W2065774507 @default.
• W2080557402 cites W2072955178 @default.
• W2080557402 cites W2085646817 @default.
• W2080557402 cites W2088324956 @default.
• W2080557402 cites W2131678896 @default.
• W2080557402 cites W2322465130 @default.
• W2080557402 cites W2323126708 @default.
• W2080557402 doi "https://doi.org/10.1016/j.biopsych.2010.07.023" @default.
• W2080557402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3562997" @default.
• W2080557402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20864091" @default.
• W2080557402 hasPublicationYear "2010" @default.
• W2080557402 type Work @default.
• W2080557402 sameAs 2080557402 @default.
• W2080557402 citedByCount "39" @default.
• W2080557402 countsByYear W20805574022012 @default.
• W2080557402 countsByYear W20805574022013 @default.
• W2080557402 countsByYear W20805574022014 @default.
• W2080557402 countsByYear W20805574022015 @default.
• W2080557402 countsByYear W20805574022016 @default.
• W2080557402 countsByYear W20805574022017 @default.
• W2080557402 countsByYear W20805574022018 @default.
• W2080557402 countsByYear W20805574022019 @default.
• W2080557402 countsByYear W20805574022020 @default.
• W2080557402 countsByYear W20805574022021 @default.
• W2080557402 countsByYear W20805574022022 @default.
• W2080557402 crossrefType "journal-article" @default.
• W2080557402 hasAuthorship W2080557402A5002190224 @default.
• W2080557402 hasAuthorship W2080557402A5024198476 @default.
• W2080557402 hasAuthorship W2080557402A5044317538 @default.
• W2080557402 hasAuthorship W2080557402A5047587284 @default.
• W2080557402 hasAuthorship W2080557402A5063642220 @default.
• W2080557402 hasAuthorship W2080557402A5073705350 @default.
• W2080557402 hasAuthorship W2080557402A5083352205 @default.
• W2080557402 hasBestOaLocation W20805574022 @default.
• W2080557402 hasConcept C118716 @default.
• W2080557402 hasConcept C126322002 @default.
• W2080557402 hasConcept C134018914 @default.
• W2080557402 hasConcept C170493617 @default.
• W2080557402 hasConcept C176303035 @default.
• W2080557402 hasConcept C181199279 @default.
• W2080557402 hasConcept C185592680 @default.
• W2080557402 hasConcept C187714386 @default.
• W2080557402 hasConcept C2775864247 @default.
• W2080557402 hasConcept C2776668983 @default.
• W2080557402 hasConcept C2778938600 @default.
• W2080557402 hasConcept C2779177272 @default.
• W2080557402 hasConcept C2779178603 @default.
• W2080557402 hasConcept C2781161787 @default.
• W2080557402 hasConcept C55493867 @default.
• W2080557402 hasConcept C71924100 @default.
• W2080557402 hasConcept C80631254 @default.
• W2080557402 hasConceptScore W2080557402C118716 @default.
• W2080557402 hasConceptScore W2080557402C126322002 @default.
• W2080557402 hasConceptScore W2080557402C134018914 @default.
• W2080557402 hasConceptScore W2080557402C170493617 @default.
• W2080557402 hasConceptScore W2080557402C176303035 @default.
• W2080557402 hasConceptScore W2080557402C181199279 @default.
• W2080557402 hasConceptScore W2080557402C185592680 @default.
• W2080557402 hasConceptScore W2080557402C187714386 @default.
• W2080557402 hasConceptScore W2080557402C2775864247 @default.
• W2080557402 hasConceptScore W2080557402C2776668983 @default.
• W2080557402 hasConceptScore W2080557402C2778938600 @default.
• W2080557402 hasConceptScore W2080557402C2779177272 @default.
• W2080557402 hasConceptScore W2080557402C2779178603 @default.
• W2080557402 hasConceptScore W2080557402C2781161787 @default.
• W2080557402 hasConceptScore W2080557402C55493867 @default.
• W2080557402 hasConceptScore W2080557402C71924100 @default.
• W2080557402 hasConceptScore W2080557402C80631254 @default.
• W2080557402 hasFunder F4320307758 @default.
• W2080557402 hasIssue "9" @default.
• W2080557402 hasLocation W20805574021 @default.
• W2080557402 hasLocation W20805574022 @default.
• W2080557402 hasLocation W20805574023 @default.
• W2080557402 hasLocation W20805574024 @default.

• next