FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080561323> ?p ?o ?g. }

• W2080561323 endingPage "2009" @default.
• W2080561323 startingPage "2003" @default.
• W2080561323 abstract "The objective of this study was to investigate whether depolarization of cultured endothelial cells (human umbilical vein endothelial cells, HUVECs) affects their ectonucleotidase activity through superoxide (O2-) production.Depolarization by the cation channel gramicidin (100 nmol/L) or tetrabutylammonium chloride (1 mmol/L) induced O2- release from HUVECs (n=4), which was decreased by superoxide dismutase (SOD, 500 U/mL). The activity of endothelial ectonucleotidases was assessed by the production of inorganic phosphate from ADP, which was decreased by chronic depolarization by 25% (n=6, P<0.05) and the amount of AMP derived from ADP in the presence of the 5'-nucleotidase inhibitor alpha,beta-methylene-5'-diphosphate (100 micromol/L). AMP was decreased by chronic depolarization from 0.54+/-0.16 to 0.39+/-0.11 micromol/min/mg protein (n=6, P<0.05). This was abolished in the continuous presence of SOD (n=6). NTPDase protein was predominantly expressed in HUVECs (n=4). Protein abundance, viability of cells, and apoptosis rates were not altered by depolarization (n=10). Only in the presence of depolarized HUVECs, but not with control cells or with HUVECs depolarized in the presence of SOD, did 5 micromol/L of ADP cause irreversible platelet aggregation. Increases in transmural pressure induced endothelial depolarization in intact hamster small arterioles.Depolarization causes the endothelial production of O2-, which inhibits the activity of endothelial ectonucleotidases. Increases in transmural pressure induce endothelial depolarization. In chronically hypertensive diseases, depolarization might favor platelet aggregation." @default.
• W2080561323 created "2016-06-24" @default.
• W2080561323 creator A5001557568 @default.
• W2080561323 creator A5009817680 @default.
• W2080561323 creator A5015996015 @default.
• W2080561323 creator A5037487334 @default.
• W2080561323 creator A5042610251 @default.
• W2080561323 creator A5070560020 @default.
• W2080561323 creator A5075585589 @default.
• W2080561323 date "2002-12-01" @default.
• W2080561323 modified "2023-09-25" @default.
• W2080561323 title "Depolarization of Endothelial Cells Enhances Platelet Aggregation Through Oxidative Inactivation of Endothelial NTPDase" @default.
• W2080561323 cites W1519164650 @default.
• W2080561323 cites W1540295714 @default.
• W2080561323 cites W1565285014 @default.
• W2080561323 cites W1811799314 @default.
• W2080561323 cites W1891400074 @default.
• W2080561323 cites W1976342357 @default.
• W2080561323 cites W1981905227 @default.
• W2080561323 cites W1996629436 @default.
• W2080561323 cites W2002451448 @default.
• W2080561323 cites W2011492906 @default.
• W2080561323 cites W2033981667 @default.
• W2080561323 cites W2035619942 @default.
• W2080561323 cites W2036750318 @default.
• W2080561323 cites W2042101459 @default.
• W2080561323 cites W2044014719 @default.
• W2080561323 cites W2046382647 @default.
• W2080561323 cites W2061131715 @default.
• W2080561323 cites W2064061284 @default.
• W2080561323 cites W2077930885 @default.
• W2080561323 cites W2079875269 @default.
• W2080561323 cites W2082552881 @default.
• W2080561323 cites W2090749314 @default.
• W2080561323 cites W2092447579 @default.
• W2080561323 cites W2105649992 @default.
• W2080561323 cites W2117204128 @default.
• W2080561323 cites W2137570167 @default.
• W2080561323 cites W2138599948 @default.
• W2080561323 cites W2171678969 @default.
• W2080561323 cites W2187825253 @default.
• W2080561323 cites W2414813949 @default.
• W2080561323 cites W2441648527 @default.
• W2080561323 cites W3194355700 @default.
• W2080561323 cites W4229980946 @default.
• W2080561323 cites W4239479777 @default.
• W2080561323 cites W4247447932 @default.
• W2080561323 cites W4361865076 @default.
• W2080561323 cites W1512144932 @default.
• W2080561323 doi "https://doi.org/10.1161/01.atv.0000043454.08172.51" @default.
• W2080561323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12482826" @default.
• W2080561323 hasPublicationYear "2002" @default.
• W2080561323 type Work @default.
• W2080561323 sameAs 2080561323 @default.
• W2080561323 citedByCount "34" @default.
• W2080561323 countsByYear W20805613232012 @default.
• W2080561323 countsByYear W20805613232013 @default.
• W2080561323 countsByYear W20805613232015 @default.
• W2080561323 countsByYear W20805613232017 @default.
• W2080561323 countsByYear W20805613232018 @default.
• W2080561323 countsByYear W20805613232021 @default.
• W2080561323 countsByYear W20805613232022 @default.
• W2080561323 crossrefType "journal-article" @default.
• W2080561323 hasAuthorship W2080561323A5001557568 @default.
• W2080561323 hasAuthorship W2080561323A5009817680 @default.
• W2080561323 hasAuthorship W2080561323A5015996015 @default.
• W2080561323 hasAuthorship W2080561323A5037487334 @default.
• W2080561323 hasAuthorship W2080561323A5042610251 @default.
• W2080561323 hasAuthorship W2080561323A5070560020 @default.
• W2080561323 hasAuthorship W2080561323A5075585589 @default.
• W2080561323 hasBestOaLocation W20805613231 @default.
• W2080561323 hasConcept C123012128 @default.
• W2080561323 hasConcept C12554922 @default.
• W2080561323 hasConcept C181199279 @default.
• W2080561323 hasConcept C185592680 @default.
• W2080561323 hasConcept C202751555 @default.
• W2080561323 hasConcept C2775838275 @default.
• W2080561323 hasConcept C2776151105 @default.
• W2080561323 hasConcept C2777411675 @default.
• W2080561323 hasConcept C2780795997 @default.
• W2080561323 hasConcept C4141045 @default.
• W2080561323 hasConcept C55493867 @default.
• W2080561323 hasConcept C86803240 @default.
• W2080561323 hasConceptScore W2080561323C123012128 @default.
• W2080561323 hasConceptScore W2080561323C12554922 @default.
• W2080561323 hasConceptScore W2080561323C181199279 @default.
• W2080561323 hasConceptScore W2080561323C185592680 @default.
• W2080561323 hasConceptScore W2080561323C202751555 @default.
• W2080561323 hasConceptScore W2080561323C2775838275 @default.
• W2080561323 hasConceptScore W2080561323C2776151105 @default.
• W2080561323 hasConceptScore W2080561323C2777411675 @default.
• W2080561323 hasConceptScore W2080561323C2780795997 @default.
• W2080561323 hasConceptScore W2080561323C4141045 @default.
• W2080561323 hasConceptScore W2080561323C55493867 @default.
• W2080561323 hasConceptScore W2080561323C86803240 @default.
• W2080561323 hasIssue "12" @default.
• W2080561323 hasLocation W20805613231 @default.
• W2080561323 hasLocation W20805613232 @default.

• next