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- W2080563233 endingPage "281" @default.
- W2080563233 startingPage "255" @default.
- W2080563233 abstract "To systematically assess the literature regarding the clinical, histological, and radiographic outcome of bone morphogenetic proteins (BMP-2, BMP-7), growth/differentiation factor-5 (GDF-5), platelet-derived growth factor (PDGF), and parathyroid hormone (PTH) for localized alveolar ridge augmentation.Five separate Medline searches were performed in duplicate for human and animal studies, respectively. The primary outcome of the included studies was bone regeneration of localized alveolar ridge defects or craniofacial defects.In six human studies, BMP-2 affected local bone augmentation with increasing volume for higher doses. A majority (43 of 45) of animal studies using BMP-2 showed a positive effect in favour of the growth factor (GF). In six of eight studies, a positive effect was associated with the use of BMP-7. Only one animal study was included for GDF-5 revealing statistically significantly higher bone volume. Regarding PDGF, statistically significantly higher bone volume was observed in five of 10 included studies. Four animal studies using PTH revealed statistically significantly more bone regeneration compared with controls.Differing levels and quantity of evidence were noted to be available for the GFs evaluated, revealing that BMP-2, BMP-7, GDF-5, PDGF, and PTH may stimulate local bone augmentation to various degrees. Human data for the potential of rhBMP-2 are supportive." @default.
- W2080563233 created "2016-06-24" @default.
- W2080563233 creator A5013941307 @default.
- W2080563233 creator A5028822060 @default.
- W2080563233 creator A5036414620 @default.
- W2080563233 date "2008-09-01" @default.
- W2080563233 modified "2023-09-26" @default.
- W2080563233 title "Assessment of the potential of growth factors for localized alveolar ridge augmentation: a systematic review" @default.
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