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• W2080571337 abstract "Platelet derived growth factor (PDGF) has been shown to induce c-fos and c-myc proto-oncogenes. In the present study, we investigated the effects of genistein, a tyrosine kinase inhibitor, and NiCl2, a Ca2+ influx blocker, on PDGF-induced Ca2+ transient and on expression of c-fos and c-myc mRNA. In the presence of extracellular Ca2+, PDGF induced elevation of intracellular Ca2+ concentration ([Ca2+]i) and increases in c-fos and c-myc mRNA, as detected by reverse transcription polymerase chain reaction (RT-PCR) and Northern hybridization. PDGF-induced [Ca2+]i elevation was composed of an initial transient increase (first component) followed by steady state elevation (second component). Genistein (10 microM) blocked the 1st, but not the 2nd, component of [Ca2+]i elevation induced by PDGF. NiCl2 (1 mM) and removal of extracellular Ca2+ inhibited the 2nd, but not the 1st, component. In the presence of 10 microM genistein and 1 mM NiCl2, PDGF induced c-fos and c-myc mRNA, although the [Ca2+]i elevation could be completely blocked by these two agents. These results indicate that elevation of [Ca2+]i is not a prerequisite condition for PDGF to induce c-fos and/or c-myc mRNA in rat aortic smooth muscle cells in primary culture." @default.
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• W2080571337 date "1992-11-01" @default.
• W2080571337 modified "2023-10-16" @default.
• W2080571337 title "Platelet derived growth factor induces C-fos and C-myc mRNA in rat aortic smooth muscle cells in primary culture without elevation of intracellular Ca2+ concentration" @default.
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• W2080571337 doi "https://doi.org/10.1016/0006-291x(92)91358-w" @default.
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