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• W2080574228 abstract "The implication of serotonin in suicide and affective disease explains why the 5-HT(2A) receptor gene has been proposed as a candidate gene in these disorders, although with conflicting results.We analysed the distribution of the 5-HT(2A)-1438A/G genetic polymorphism in 192 patients with major affective disorder (127 bipolar disorders and 65 unipolar disorders) compared to 142 healthy control subjects.We found a higher frequency of the A allele in affected patients than in control subjects (p =.034), this difference being particularly striking for the subgroup of patients with type I bipolar disorder (p =.015). Patients with no personal and/or familial history of suicide attempts mainly accounted for the excess of the A allele in affected patients.The association detected in this study suggests that the 5-HT(2A) receptor gene may play a role in the genetic susceptibility to bipolar disorder, through a specific subgroup of bipolar type I patients with lower risk of suicidal behavior." @default.
• W2080574228 created "2016-06-24" @default.
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• W2080574228 date "2002-05-01" @default.
• W2080574228 modified "2023-09-30" @default.
• W2080574228 title "Association of 5-HT2A receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk" @default.
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• W2080574228 doi "https://doi.org/10.1016/s0006-3223(01)01228-8" @default.
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