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• W2080574265 abstract "You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Medical and Non-Surgical Therapy1 Apr 20111671 THE EFFECT OF SIMVASTATIN ON PENILE ERECTION IN PATIENTS WITH ALTERED C-REACTIVE PROTEIN: A RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED CLINICAL TRIAL (STED TRIAL) Eduardo Mastalir, Gustavo Carvalhal, and Vera Portal Eduardo MastalirEduardo Mastalir Porto Alegre, Brazil More articles by this author , Gustavo CarvalhalGustavo Carvalhal Porto Alegre, Brazil More articles by this author , and Vera PortalVera Portal Porto Alegre, Brazil More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1825AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recent evidence has suggested that erectile dysfunction (ED) is strongly correlated with other correlates of endothelial dysfunction. Current knowledge about the physiopathology of ED has led to the development of clinical trials investigating the role of statins in men with ED. However, published data about the interaction of ED and statins are sparse and conflicting. The objective of this study is to evaluate the effect of simvastatin in ED secondary to endothelial dysfunction. METHODS Double blind, randomized, clinical trial in patients with ED and endothelial dysfunction defined by ultrasensitive C-reactive protein (usCRP) levels ≥ 1.1 mg/L (NCT00947323). Patients were randomized to receive 20 mg simvastatin (n=21) or placebo (n=20) daily, for six months. Subsequently, patients of both groups were prescribed 10mg of vardenafil on demand for four weeks. Serum cholesterol, hormone profile, usCRP, the International Index of Erectile Dysfunction (IIEF) and the ED Index of Treatment Satisfaction (EDITS) were evaluated. RESULTS There was a significant reduction of the serum cholesterol in the treatment group. The hormonal profile remained unaltered. The reduction of the usCRP levels were of 32% (P=0.376) in the simvastatin group, and of 8.3% (P=0.266) in the placebo group. The IIEF-5 improved significantly from 13.33 ± 6.33 to 22.77 ± 3.68 (P<0.001), although without difference to placebo (from 11.16 ± 7.81 to 22.22 ± 4.50, P=0.733). At the beginning, 26% of the patients of both groups presented with mild ED and 74% with moderate to severe ED; at the end of the seventh month, all patients from the simvastatin group progressed to mild ED, compared to only 83% in the placebo group. CONCLUSIONS Simvastatin did not determine a statistically significant improvement of erectile function compared to placebo. However, changes in the severity of ED suggest that simvastatin may be benefitial to patients with ED and endothelial dysfunction. Further studies are necessary to verify this hypothesis. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e671 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Eduardo Mastalir Porto Alegre, Brazil More articles by this author Gustavo Carvalhal Porto Alegre, Brazil More articles by this author Vera Portal Porto Alegre, Brazil More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2080574265 title "1671 THE EFFECT OF SIMVASTATIN ON PENILE ERECTION IN PATIENTS WITH ALTERED C-REACTIVE PROTEIN: A RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED CLINICAL TRIAL (STED TRIAL)" @default.
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