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- W2080574895 abstract "Some psychiatric illnesses involve a learned component. For example, in posttraumatic stress disorder, memories triggered by trauma-associated cues trigger fear and anxiety, and in addiction, drug-associated cues elicit drug craving and withdrawal. Clinical interventions to reduce the impact of conditioned cues in eliciting these maladaptive conditioned responses are likely to be beneficial. Extinction is a method of lessening conditioned responses and involves repeated exposures to a cue in the absence of the event it once predicted. We believe that an improved understanding of the behavioral and neurobiological mechanisms of extinction will allow extinction-like procedures in the clinic to become more effective. Research on the role of glutamate—the major excitatory neurotransmitter in the mammalian brain—in extinction has led to the development of pharmacotherapeutics to enhance the efficacy of extinction-based protocols in clinical populations. In this review, we describe what has been learned about glutamate actions at its three major receptor types (N-methyl--aspartate (NMDA) receptors, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, and metabotropic glutamate receptors) in the extinction of conditioned fear, drug craving, and withdrawal. We then discuss how these findings have been applied in clinical research." @default.
- W2080574895 created "2016-06-24" @default.
- W2080574895 creator A5020998015 @default.
- W2080574895 creator A5024383091 @default.
- W2080574895 creator A5054138504 @default.
- W2080574895 date "2010-07-14" @default.
- W2080574895 modified "2023-10-18" @default.
- W2080574895 title "Glutamate Receptors in Extinction and Extinction-Based Therapies for Psychiatric Illness" @default.
- W2080574895 cites W108549460 @default.
- W2080574895 cites W1500759439 @default.
- W2080574895 cites W1506117520 @default.
- W2080574895 cites W1509990832 @default.
- W2080574895 cites W1525373779 @default.
- W2080574895 cites W1527550792 @default.
- W2080574895 cites W1557569458 @default.
- W2080574895 cites W1557933310 @default.
- W2080574895 cites W1585501195 @default.
- W2080574895 cites W1608785134 @default.
- W2080574895 cites W1618945825 @default.
- W2080574895 cites W1635002850 @default.
- W2080574895 cites W1791997487 @default.
- W2080574895 cites W1876061808 @default.
- W2080574895 cites W1946000001 @default.
- W2080574895 cites W1959821071 @default.
- W2080574895 cites W1963854355 @default.
- W2080574895 cites W1966767061 @default.
- W2080574895 cites W1966879038 @default.
- W2080574895 cites W1969422606 @default.
- W2080574895 cites W1969627689 @default.
- W2080574895 cites W1970050718 @default.
- W2080574895 cites W1970316545 @default.
- W2080574895 cites W1970885260 @default.
- W2080574895 cites W1971303103 @default.
- W2080574895 cites W1972692021 @default.
- W2080574895 cites W1972758800 @default.
- W2080574895 cites W1972799025 @default.
- W2080574895 cites W1974533386 @default.
- W2080574895 cites W1977077283 @default.
- W2080574895 cites W1977313055 @default.
- W2080574895 cites W1978199448 @default.
- W2080574895 cites W1979366184 @default.
- W2080574895 cites W1979708002 @default.
- W2080574895 cites W1980985589 @default.
- W2080574895 cites W1981032252 @default.
- W2080574895 cites W1981597802 @default.
- W2080574895 cites W1981710302 @default.
- W2080574895 cites W1983090694 @default.
- W2080574895 cites W1984624029 @default.
- W2080574895 cites W1988068086 @default.
- W2080574895 cites W1988387688 @default.
- W2080574895 cites W1988744087 @default.
- W2080574895 cites W1989045560 @default.
- W2080574895 cites W1991036243 @default.
- W2080574895 cites W1995412725 @default.
- W2080574895 cites W1995629399 @default.
- W2080574895 cites W1997211693 @default.
- W2080574895 cites W1998041825 @default.
- W2080574895 cites W1998465031 @default.
- W2080574895 cites W1998808152 @default.
- W2080574895 cites W2000795527 @default.
- W2080574895 cites W2001364874 @default.
- W2080574895 cites W2001562560 @default.
- W2080574895 cites W2003039924 @default.
- W2080574895 cites W2005245722 @default.
- W2080574895 cites W2005856089 @default.
- W2080574895 cites W2009000833 @default.
- W2080574895 cites W2011779179 @default.
- W2080574895 cites W2012639198 @default.
- W2080574895 cites W2014376853 @default.
- W2080574895 cites W2015770607 @default.
- W2080574895 cites W2016295830 @default.
- W2080574895 cites W2016554932 @default.
- W2080574895 cites W2017160314 @default.
- W2080574895 cites W2017169966 @default.
- W2080574895 cites W2017579592 @default.
- W2080574895 cites W2018162107 @default.
- W2080574895 cites W2018876606 @default.
- W2080574895 cites W2020112095 @default.
- W2080574895 cites W2026609418 @default.
- W2080574895 cites W2026678817 @default.
- W2080574895 cites W2027154295 @default.
- W2080574895 cites W2028385892 @default.
- W2080574895 cites W2028386401 @default.
- W2080574895 cites W2028445187 @default.
- W2080574895 cites W2030916528 @default.
- W2080574895 cites W2031724615 @default.
- W2080574895 cites W2033663562 @default.
- W2080574895 cites W2036681307 @default.
- W2080574895 cites W2036881580 @default.
- W2080574895 cites W2037663859 @default.
- W2080574895 cites W2037877714 @default.
- W2080574895 cites W2038335379 @default.
- W2080574895 cites W2038466901 @default.
- W2080574895 cites W2038556607 @default.
- W2080574895 cites W2039743590 @default.
- W2080574895 cites W2040164628 @default.
- W2080574895 cites W2041150117 @default.
- W2080574895 cites W2041329554 @default.