FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080574911> ?p ?o ?g. }

• W2080574911 abstract "Therapy-related acute myeloid leukemia (t-AML) is a secondary, generally incurable, malignancy attributable to chemotherapy exposure. Although there is a genetic component to t-AML susceptibility in mice, the relevant loci and the mechanism(s) by which they contribute to t-AML are largely unknown. An improved understanding of susceptibility factors and the biological processes in which they act may lead to the development of t-AML prevention strategies. In this work we applied an integrated genomics strategy in inbred strains of mice to find novel factors that might contribute to susceptibility. We found that the pre-exposure transcriptional state of hematopoietic stem/progenitor cells predicts susceptibility status. More than 900 genes were differentially expressed between susceptible and resistant strains and were highly enriched in the apoptotic program, but it remained unclear which genes, if any, contribute directly to t-AML susceptibility. To address this issue, we integrated gene expression data with genetic information, including single nucleotide polymorphisms (SNPs) and DNA copy number variants (CNVs), to identify genetic networks underlying t-AML susceptibility. The 30 t-AML susceptibility networks we found are robust: they were validated in independent, previously published expression data, and different analytical methods converge on them. Further, the networks are enriched in genes involved in cell cycle and DNA repair (pathways not discovered in traditional differential expression analysis), suggesting that these processes contribute to t-AML susceptibility. Within these networks, the putative regulators (e.g., Parp2, Casp9, Polr1b) are the most likely to have a non-redundant role in the pathogenesis of t-AML. While identifying these networks, we found that current CNVR and SNP-based haplotype maps in mice represented distinct sources of genetic variation contributing to expression variation, implying that mapping studies utilizing either source alone will have reduced sensitivity. The identification and prioritization of genes and networks not previously implicated in t-AML generates novel hypotheses on the biology and treatment of this disease that will be the focus of future research." @default.
• W2080574911 created "2016-06-24" @default.
• W2080574911 creator A5004108540 @default.
• W2080574911 creator A5056921013 @default.
• W2080574911 date "2010-11-17" @default.
• W2080574911 modified "2023-10-16" @default.
• W2080574911 title "Integrated genomics of susceptibility to alkylator-induced leukemia in mice" @default.
• W2080574911 cites W1546952499 @default.
• W2080574911 cites W1702002942 @default.
• W2080574911 cites W1964123743 @default.
• W2080574911 cites W1964895626 @default.
• W2080574911 cites W1966179399 @default.
• W2080574911 cites W1971422405 @default.
• W2080574911 cites W1973651601 @default.
• W2080574911 cites W1976634335 @default.
• W2080574911 cites W1978093163 @default.
• W2080574911 cites W1986660401 @default.
• W2080574911 cites W1995395947 @default.
• W2080574911 cites W1999226378 @default.
• W2080574911 cites W2000352412 @default.
• W2080574911 cites W2010517054 @default.
• W2080574911 cites W2016296894 @default.
• W2080574911 cites W2017444651 @default.
• W2080574911 cites W2017459547 @default.
• W2080574911 cites W2022216532 @default.
• W2080574911 cites W2034405939 @default.
• W2080574911 cites W2047031939 @default.
• W2080574911 cites W2047361940 @default.
• W2080574911 cites W2048940082 @default.
• W2080574911 cites W2050499823 @default.
• W2080574911 cites W2057960967 @default.
• W2080574911 cites W2060022136 @default.
• W2080574911 cites W2064253158 @default.
• W2080574911 cites W2065080438 @default.
• W2080574911 cites W2076357866 @default.
• W2080574911 cites W2078702698 @default.
• W2080574911 cites W2083912192 @default.
• W2080574911 cites W2088609959 @default.
• W2080574911 cites W2097797646 @default.
• W2080574911 cites W2106390123 @default.
• W2080574911 cites W2106510321 @default.
• W2080574911 cites W2109108939 @default.
• W2080574911 cites W2109869458 @default.
• W2080574911 cites W2112087830 @default.
• W2080574911 cites W2114332551 @default.
• W2080574911 cites W2117007075 @default.
• W2080574911 cites W2118308505 @default.
• W2080574911 cites W2120473562 @default.
• W2080574911 cites W2121021837 @default.
• W2080574911 cites W2132800189 @default.
• W2080574911 cites W2138163973 @default.
• W2080574911 cites W2148305047 @default.
• W2080574911 cites W2157619703 @default.
• W2080574911 cites W2158217645 @default.
• W2080574911 cites W2165064967 @default.
• W2080574911 cites W2168312688 @default.
• W2080574911 cites W2169753036 @default.
• W2080574911 cites W2169986196 @default.
• W2080574911 cites W36679969 @default.
• W2080574911 cites W4255885845 @default.
• W2080574911 doi "https://doi.org/10.1186/1471-2164-11-638" @default.
• W2080574911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3018144" @default.
• W2080574911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21080971" @default.
• W2080574911 hasPublicationYear "2010" @default.
• W2080574911 type Work @default.
• W2080574911 sameAs 2080574911 @default.
• W2080574911 citedByCount "5" @default.
• W2080574911 countsByYear W20805749112012 @default.
• W2080574911 countsByYear W20805749112013 @default.
• W2080574911 countsByYear W20805749112023 @default.
• W2080574911 crossrefType "journal-article" @default.
• W2080574911 hasAuthorship W2080574911A5004108540 @default.
• W2080574911 hasAuthorship W2080574911A5056921013 @default.
• W2080574911 hasBestOaLocation W20805749111 @default.
• W2080574911 hasConcept C104317684 @default.
• W2080574911 hasConcept C109159458 @default.
• W2080574911 hasConcept C134935766 @default.
• W2080574911 hasConcept C135763542 @default.
• W2080574911 hasConcept C141231307 @default.
• W2080574911 hasConcept C150194340 @default.
• W2080574911 hasConcept C153209595 @default.
• W2080574911 hasConcept C189206191 @default.
• W2080574911 hasConcept C2778729363 @default.
• W2080574911 hasConcept C2779282312 @default.
• W2080574911 hasConcept C28328180 @default.
• W2080574911 hasConcept C502942594 @default.
• W2080574911 hasConcept C54355233 @default.
• W2080574911 hasConcept C67636389 @default.
• W2080574911 hasConcept C86803240 @default.
• W2080574911 hasConcept C95371953 @default.
• W2080574911 hasConceptScore W2080574911C104317684 @default.
• W2080574911 hasConceptScore W2080574911C109159458 @default.
• W2080574911 hasConceptScore W2080574911C134935766 @default.
• W2080574911 hasConceptScore W2080574911C135763542 @default.
• W2080574911 hasConceptScore W2080574911C141231307 @default.
• W2080574911 hasConceptScore W2080574911C150194340 @default.
• W2080574911 hasConceptScore W2080574911C153209595 @default.
• W2080574911 hasConceptScore W2080574911C189206191 @default.
• W2080574911 hasConceptScore W2080574911C2778729363 @default.
• W2080574911 hasConceptScore W2080574911C2779282312 @default.

• next