Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080576005> ?p ?o ?g. }
- W2080576005 endingPage "358" @default.
- W2080576005 startingPage "352" @default.
- W2080576005 abstract "Diabetic polyneuropathy aetiology is based on oxidative stress generation due to production of reactive oxygen species. Ubiquinone is reduced to ubiquinol and redistributed into lipoproteins, possibly to protect them from oxidation. To evaluate the impact of oral ubiquinone in diabetic polyneuropathy, and the role of lipid peroxidation (LPO) and nerve growth factor (NGF-β). We conducted a double-blind, placebo-controlled clinical trial, patients were randomized to ubiquinone (400 mg) or placebo daily for 12 weeks. Main outcomes were clinical scores, nerve conduction studies, LPO, NGF-β and safety. Twenty four patients on experimental group and twenty five on control group met the inclusion criteria (mean age 56 years, 22% male and 78% female, mean evolution of type 2 diabetes mellitus 10.7 years). Significant improvement on experimental vs control group was found in neuropathy symptoms score (from 2.5 ± 0.7 to 1 ± 0.8, p < 0.001), neuropathy impairment score (5.5 ± 4 to 3.1 ± 2.6, p < 0.001), sural sensory nerve amplitude (13.0 ± 6.1 to 15.8 ± 5.1 μV, p = 0.049), peroneal motor nerve conduction velocity (39.7 ± 5.0 to 47.8 ± 4.9 m/s, p = 0.047), and ulnar motor nerve conduction velocity (48.8 ± 6.8 to 54.5 ± 6.1 m/s, p = 0.046). There was a significant reduction of LPO in subjects treated with ubiquinone vs placebo (16.7 ± 8.6 and 23.2 ± 15.8 nmol/mL, respectively) with p < 0.05, and NGF-β did not change (control 66.5 ± 26.7 vs. experimental 66.8 ± 28.4 pg/mL, p = 0.856). No drug-related adverse reactions were reported. Twelve weeks treatment with ubiquinone improves clinical outcomes and nerve conduction parameters of diabetic polyneuropathy; furthermore, it reduces oxidative stress without significant adverse events." @default.
- W2080576005 created "2016-06-24" @default.
- W2080576005 creator A5012890595 @default.
- W2080576005 creator A5023088778 @default.
- W2080576005 creator A5049783512 @default.
- W2080576005 creator A5059311832 @default.
- W2080576005 creator A5062309385 @default.
- W2080576005 creator A5081209748 @default.
- W2080576005 creator A5081557030 @default.
- W2080576005 creator A5088205036 @default.
- W2080576005 date "2012-07-01" @default.
- W2080576005 modified "2023-09-27" @default.
- W2080576005 title "The effect of ubiquinone in diabetic polyneuropathy: A randomized double-blind placebo-controlled study" @default.
- W2080576005 cites W1968561916 @default.
- W2080576005 cites W1991952322 @default.
- W2080576005 cites W2004051793 @default.
- W2080576005 cites W2006981186 @default.
- W2080576005 cites W2007761806 @default.
- W2080576005 cites W2012234591 @default.
- W2080576005 cites W2013131099 @default.
- W2080576005 cites W2037682503 @default.
- W2080576005 cites W2042157082 @default.
- W2080576005 cites W2044437167 @default.
- W2080576005 cites W2053814042 @default.
- W2080576005 cites W2071474384 @default.
- W2080576005 cites W2079542761 @default.
- W2080576005 cites W2083658185 @default.
- W2080576005 cites W2107385980 @default.
- W2080576005 cites W2113384757 @default.
- W2080576005 cites W2115110594 @default.
- W2080576005 cites W2115341402 @default.
- W2080576005 cites W2122404656 @default.
- W2080576005 cites W2125316317 @default.
- W2080576005 cites W2135932738 @default.
- W2080576005 cites W2136502820 @default.
- W2080576005 cites W2136948852 @default.
- W2080576005 cites W2163541332 @default.
- W2080576005 cites W2171471740 @default.
- W2080576005 cites W2325861371 @default.
- W2080576005 doi "https://doi.org/10.1016/j.jdiacomp.2012.04.004" @default.
- W2080576005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22595020" @default.
- W2080576005 hasPublicationYear "2012" @default.
- W2080576005 type Work @default.
- W2080576005 sameAs 2080576005 @default.
- W2080576005 citedByCount "39" @default.
- W2080576005 countsByYear W20805760052012 @default.
- W2080576005 countsByYear W20805760052013 @default.
- W2080576005 countsByYear W20805760052014 @default.
- W2080576005 countsByYear W20805760052015 @default.
- W2080576005 countsByYear W20805760052016 @default.
- W2080576005 countsByYear W20805760052018 @default.
- W2080576005 countsByYear W20805760052019 @default.
- W2080576005 countsByYear W20805760052020 @default.
- W2080576005 countsByYear W20805760052021 @default.
- W2080576005 countsByYear W20805760052022 @default.
- W2080576005 countsByYear W20805760052023 @default.
- W2080576005 crossrefType "journal-article" @default.
- W2080576005 hasAuthorship W2080576005A5012890595 @default.
- W2080576005 hasAuthorship W2080576005A5023088778 @default.
- W2080576005 hasAuthorship W2080576005A5049783512 @default.
- W2080576005 hasAuthorship W2080576005A5059311832 @default.
- W2080576005 hasAuthorship W2080576005A5062309385 @default.
- W2080576005 hasAuthorship W2080576005A5081209748 @default.
- W2080576005 hasAuthorship W2080576005A5081557030 @default.
- W2080576005 hasAuthorship W2080576005A5088205036 @default.
- W2080576005 hasConcept C126322002 @default.
- W2080576005 hasConcept C134018914 @default.
- W2080576005 hasConcept C142724271 @default.
- W2080576005 hasConcept C179253579 @default.
- W2080576005 hasConcept C202061045 @default.
- W2080576005 hasConcept C204787440 @default.
- W2080576005 hasConcept C27081682 @default.
- W2080576005 hasConcept C2775892965 @default.
- W2080576005 hasConcept C2779178840 @default.
- W2080576005 hasConcept C2991744798 @default.
- W2080576005 hasConcept C42219234 @default.
- W2080576005 hasConcept C555293320 @default.
- W2080576005 hasConcept C71924100 @default.
- W2080576005 hasConcept C90924648 @default.
- W2080576005 hasConceptScore W2080576005C126322002 @default.
- W2080576005 hasConceptScore W2080576005C134018914 @default.
- W2080576005 hasConceptScore W2080576005C142724271 @default.
- W2080576005 hasConceptScore W2080576005C179253579 @default.
- W2080576005 hasConceptScore W2080576005C202061045 @default.
- W2080576005 hasConceptScore W2080576005C204787440 @default.
- W2080576005 hasConceptScore W2080576005C27081682 @default.
- W2080576005 hasConceptScore W2080576005C2775892965 @default.
- W2080576005 hasConceptScore W2080576005C2779178840 @default.
- W2080576005 hasConceptScore W2080576005C2991744798 @default.
- W2080576005 hasConceptScore W2080576005C42219234 @default.
- W2080576005 hasConceptScore W2080576005C555293320 @default.
- W2080576005 hasConceptScore W2080576005C71924100 @default.
- W2080576005 hasConceptScore W2080576005C90924648 @default.
- W2080576005 hasIssue "4" @default.
- W2080576005 hasLocation W20805760051 @default.
- W2080576005 hasLocation W20805760052 @default.
- W2080576005 hasOpenAccess W2080576005 @default.
- W2080576005 hasPrimaryLocation W20805760051 @default.