FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080577380> ?p ?o ?g. }

• W2080577380 endingPage "1605" @default.
• W2080577380 startingPage "1599" @default.
• W2080577380 abstract "The relaxation of isolated blood vessels by acetylcholine is dependent on the presence of intact endothelium and its release of a smooth muscle relaxing nitroso-like compound. Pregnancy is associated with altered vascular responsiveness to a variety of agents. Because many of these agents stimulate the release of endothelium-derived relaxing factor, we investigated in vitro the effect of pregnancy on acetylcholine-mediated relaxation of guinea pig uterine and carotid artery rings. The presence of intact and functional endothelium was confirmed both by examination under the scanning electron microscope and by vessel relaxation after the addition of acetylcholine. The addition of acetylcholine to the vessel bath produced dose-dependent relaxation of both carotid and uterine artery segments obtained from pregnant and nonpregnant animals after they had been submaximally preconstricted with phenylephrine. There was a significant increase in both response and efficacy to acetylcholine during pregnancy for both uterine and carotid arteries (p<0.0001 for each). The concentrations of endothelial cells (cells per square micrometer) were similar in uterine arteries from pregnant and nonpregnant animals. We conclude that the most likely explanation for these findings is a pregnancy-mediated enhancement of endothelium-derived relaxing factor activity. The relaxation of isolated blood vessels by acetylcholine is dependent on the presence of intact endothelium and its release of a smooth muscle relaxing nitroso-like compound. Pregnancy is associated with altered vascular responsiveness to a variety of agents. Because many of these agents stimulate the release of endothelium-derived relaxing factor, we investigated in vitro the effect of pregnancy on acetylcholine-mediated relaxation of guinea pig uterine and carotid artery rings. The presence of intact and functional endothelium was confirmed both by examination under the scanning electron microscope and by vessel relaxation after the addition of acetylcholine. The addition of acetylcholine to the vessel bath produced dose-dependent relaxation of both carotid and uterine artery segments obtained from pregnant and nonpregnant animals after they had been submaximally preconstricted with phenylephrine. There was a significant increase in both response and efficacy to acetylcholine during pregnancy for both uterine and carotid arteries (p<0.0001 for each). The concentrations of endothelial cells (cells per square micrometer) were similar in uterine arteries from pregnant and nonpregnant animals. We conclude that the most likely explanation for these findings is a pregnancy-mediated enhancement of endothelium-derived relaxing factor activity." @default.
• W2080577380 created "2016-06-24" @default.
• W2080577380 creator A5005245196 @default.
• W2080577380 creator A5038838250 @default.
• W2080577380 creator A5041827931 @default.
• W2080577380 creator A5068713054 @default.
• W2080577380 creator A5084704033 @default.
• W2080577380 date "1989-12-01" @default.
• W2080577380 modified "2023-10-18" @default.
• W2080577380 title "In vitro release of endothelium-derived relaxing factor by acetylcholine is increased during the guinea pig pregnancy" @default.
• W2080577380 cites W1967137326 @default.
• W2080577380 cites W1987245561 @default.
• W2080577380 cites W1995686548 @default.
• W2080577380 cites W1997352314 @default.
• W2080577380 cites W2010582965 @default.
• W2080577380 cites W2020347397 @default.
• W2080577380 cites W2029081961 @default.
• W2080577380 cites W2029700368 @default.
• W2080577380 cites W2040074029 @default.
• W2080577380 cites W2046310089 @default.
• W2080577380 cites W2050432271 @default.
• W2080577380 cites W2052235643 @default.
• W2080577380 cites W2054644175 @default.
• W2080577380 cites W2077563196 @default.
• W2080577380 cites W2077798043 @default.
• W2080577380 cites W2079274039 @default.
• W2080577380 cites W2083498400 @default.
• W2080577380 cites W2092145002 @default.
• W2080577380 cites W2098108865 @default.
• W2080577380 cites W2160482476 @default.
• W2080577380 cites W2164811702 @default.
• W2080577380 cites W2169182236 @default.
• W2080577380 cites W2419678669 @default.
• W2080577380 cites W4230944446 @default.
• W2080577380 doi "https://doi.org/10.1016/0002-9378(89)90933-2" @default.
• W2080577380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2603916" @default.
• W2080577380 hasPublicationYear "1989" @default.
• W2080577380 type Work @default.
• W2080577380 sameAs 2080577380 @default.
• W2080577380 citedByCount "117" @default.
• W2080577380 countsByYear W20805773802012 @default.
• W2080577380 countsByYear W20805773802014 @default.
• W2080577380 countsByYear W20805773802018 @default.
• W2080577380 crossrefType "journal-article" @default.
• W2080577380 hasAuthorship W2080577380A5005245196 @default.
• W2080577380 hasAuthorship W2080577380A5038838250 @default.
• W2080577380 hasAuthorship W2080577380A5041827931 @default.
• W2080577380 hasAuthorship W2080577380A5068713054 @default.
• W2080577380 hasAuthorship W2080577380A5084704033 @default.
• W2080577380 hasConcept C120770815 @default.
• W2080577380 hasConcept C126322002 @default.
• W2080577380 hasConcept C134018914 @default.
• W2080577380 hasConcept C2775910092 @default.
• W2080577380 hasConcept C2776992346 @default.
• W2080577380 hasConcept C2777663904 @default.
• W2080577380 hasConcept C2777952589 @default.
• W2080577380 hasConcept C2779395532 @default.
• W2080577380 hasConcept C2780310817 @default.
• W2080577380 hasConcept C2992686903 @default.
• W2080577380 hasConcept C71924100 @default.
• W2080577380 hasConcept C84393581 @default.
• W2080577380 hasConceptScore W2080577380C120770815 @default.
• W2080577380 hasConceptScore W2080577380C126322002 @default.
• W2080577380 hasConceptScore W2080577380C134018914 @default.
• W2080577380 hasConceptScore W2080577380C2775910092 @default.
• W2080577380 hasConceptScore W2080577380C2776992346 @default.
• W2080577380 hasConceptScore W2080577380C2777663904 @default.
• W2080577380 hasConceptScore W2080577380C2777952589 @default.
• W2080577380 hasConceptScore W2080577380C2779395532 @default.
• W2080577380 hasConceptScore W2080577380C2780310817 @default.
• W2080577380 hasConceptScore W2080577380C2992686903 @default.
• W2080577380 hasConceptScore W2080577380C71924100 @default.
• W2080577380 hasConceptScore W2080577380C84393581 @default.
• W2080577380 hasIssue "6" @default.
• W2080577380 hasLocation W20805773801 @default.
• W2080577380 hasLocation W20805773802 @default.
• W2080577380 hasOpenAccess W2080577380 @default.
• W2080577380 hasPrimaryLocation W20805773801 @default.
• W2080577380 hasRelatedWork W1044446234 @default.
• W2080577380 hasRelatedWork W1978804120 @default.
• W2080577380 hasRelatedWork W2004283605 @default.
• W2080577380 hasRelatedWork W2006842018 @default.
• W2080577380 hasRelatedWork W2055076366 @default.
• W2080577380 hasRelatedWork W2067939314 @default.
• W2080577380 hasRelatedWork W2113027232 @default.
• W2080577380 hasRelatedWork W2400017346 @default.
• W2080577380 hasRelatedWork W2417406677 @default.
• W2080577380 hasRelatedWork W74673317 @default.
• W2080577380 hasVolume "161" @default.
• W2080577380 isParatext "false" @default.
• W2080577380 isRetracted "false" @default.
• W2080577380 magId "2080577380" @default.
• W2080577380 workType "article" @default.