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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080578833> ?p ?o ?g. }

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• W2080578833 startingPage "1830" @default.
• W2080578833 abstract "A series of 3-unsubstituted/substituted-4,5-diphenyl-2-oxo-3H-1,3-oxazole derivatives were prepared as selective cyclooxygenase-2 (COX-2) inhibitors. Among the synthesized compounds, 4-(4-phenyl-3-methyl-2-oxo-3H-1,3-oxazol-5-yl)benzensulfonamide (compound 6) showed selective COX-2 inhibition with a selectivity index of >50 (IC(50)COX-1=>100 microm, IC(50)COX-2=2 microm) in purified enzyme (PE) assay. Compound 6 also exhibited selective COX-2 inhibition in human whole blood assay. Molecular docking studies showed that 6 can be docked into the COX-2 binding site thus providing the molecular basis for its activity." @default.
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• W2080578833 date "2009-05-01" @default.
• W2080578833 modified "2023-10-18" @default.
• W2080578833 title "Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors" @default.
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• W2080578833 doi "https://doi.org/10.1016/j.ejmech.2008.10.039" @default.
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