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• W2080581246 abstract "Novel, potent isoform-selective and non-selective inhibitors of heme oxygenase have been synthesized. A series of 2-oxy-substituted 1-(1 H -imidazol-1-yl)-4-phenylbutanes comprising imidazole–ketones, imidazole–dioxolanes, and imidazole–alcohols substituted with halogens in the phenyl ring were synthesized and evaluated as novel inhibitors of heme oxygenase which are structurally distinct from metalloporphyrins. The entire library of compounds was found to be highly active, with the bromine- and iodine-substituted derivatives being the most potent. The imidazole–dioxolanes were all selective for the HO-1 isozyme (inducible) and exhibited substantially lower activity toward the HO-2 isozyme (constitutive). The corresponding imidazole–ketones and imidazole–alcohols showed selectivity toward HO-1 to a lesser degree than the similarly substituted imidazole–dioxolanes." @default.
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• W2080581246 date "2007-05-01" @default.
• W2080581246 modified "2023-09-25" @default.
• W2080581246 title "Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: Effect of halogen substitution in the phenyl ring" @default.
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• W2080581246 doi "https://doi.org/10.1016/j.bmc.2007.02.034" @default.
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