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- W2080587673 abstract "We synthesized the six presumed metabolites (2—7) of 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide [KRP-197/ONO-8025, 1], a urinary incontinence therapeutic agent, in order to confirm the structures of the metabolites. Metabolite (2) was synthesized via glucuronidaion of compound (1) and methyl 2,3,4-tri-O-benzoyl-1-methanesulfonyl-α-D-glucopyranuronate. Metabolite (3) was synthesized via 3-(tert-butoxycarbonyl)-2-methyl-1,3-imidazolidine-4,5-dione. Metabolites (4—7) were synthesized via 4-amino-2-diphenylbutanamide, respectively. The structures of the metabolites (2—7) in humans were identified by means of synthesis of the authentic compounds." @default.
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- W2080587673 date "2007-01-01" @default.
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- W2080587673 title "Synthesis of the Metabolites of 4-(2-Methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide (KRP-197/ONO-8025)" @default.
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- W2080587673 doi "https://doi.org/10.1248/cpb.55.1039" @default.
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