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• W2080593374 abstract "Intensive pyrethroid use in insect control has led to resistance buildup among various pests. One alternative to battle this problem envisions the combined use of synergistically acting insecticidal compounds. Pyrethroids, scorpion alpha- and beta-toxins, and brevetoxins bind to distinct receptor sites on voltage-gated sodium channels (NaChs) and modify their function. The binding affinity of scorpion alpha-toxins to locust, but not rat-brain NaChs, is allosterically increased by pyrethroids and by brevetoxin-1. Brevetoxin-1 also increases the binding of an excitatory beta-toxin to insect NaChs. These results reveal differences between insect and mammalian NaChs and may be exploited in new strategies of insect control." @default.
• W2080593374 created "2016-06-24" @default.
• W2080593374 creator A5053799789 @default.
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• W2080593374 date "2003-03-20" @default.
• W2080593374 modified "2023-09-25" @default.
• W2080593374 title "Allosteric interactions among pyrethroid, brevetoxin, and scorpion toxin receptors on insect sodium channels raise an alternative approach for insect control" @default.
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• W2080593374 doi "https://doi.org/10.1016/s0014-5793(03)00226-6" @default.
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