FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080593507> ?p ?o ?g. }

• W2080593507 endingPage "1068" @default.
• W2080593507 startingPage "1061" @default.
• W2080593507 abstract "A small population of stem cell-like precursors in solid tumors are linked to histological composition, progression, angiogenesis, metastasis, recurrence and drug resistance of a variety of malignant tumors. Oligoastrocytoma is the most common brain mixed glioma composed of mixed cells of oligodendroglial and astrocytic phenotypes. Identification and characterization of stem cell-like precursors in oligoastrocytoma may shed light on the oncogenesis of this unique type of tumor and assist in the design of novel therapeutic strategy. Here, tumor stem cell-like precursors were identified from primary human anaplastic oligoastrocytomas by labeling of the tumor sections with nestin and CD133. Tumor cells were cultured in vitro in stem cell medium with growth factors and the capacity of the surviving stem cell-like precursors to form tumor spheres was tested. The tumor spheres were further injected subcutaneously into nude mice to observe the contribution of stem cell-like precursors to histological composition and tumor progression. We found that primary human oligoastrocytoma tissues contained nestin+/CD133+ stem cell-like precursors. These cells differentiated into tumor cells with both oligodendroglial and astrocytic characteristics and formed tumor spheres in vitro, which upon implantation in nude mice, grew into tumor nodules containing nestin +/CD133+ cells at levels higher than in the primary tumor tissues. This study revealed for the first time that anaplastic human oligoastrocytomas contained stem cell-like precursors, which exhibit neural stem cell properties with tumorigenicity. These stem cell-like precursors may be responsible for the oligodendroglial and astrocytic components of human oligoastrocytoma and should be considered as therapeutic targets." @default.
• W2080593507 created "2016-06-24" @default.
• W2080593507 creator A5002260928 @default.
• W2080593507 creator A5013049125 @default.
• W2080593507 creator A5015235892 @default.
• W2080593507 creator A5019186596 @default.
• W2080593507 creator A5030872551 @default.
• W2080593507 creator A5034471264 @default.
• W2080593507 creator A5036054973 @default.
• W2080593507 creator A5063732891 @default.
• W2080593507 creator A5075003658 @default.
• W2080593507 date "2007-10-01" @default.
• W2080593507 modified "2023-10-18" @default.
• W2080593507 title "Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma" @default.
• W2080593507 cites W1965124339 @default.
• W2080593507 cites W1972700706 @default.
• W2080593507 cites W1996784989 @default.
• W2080593507 cites W1998321969 @default.
• W2080593507 cites W2001544973 @default.
• W2080593507 cites W2009886857 @default.
• W2080593507 cites W2010317454 @default.
• W2080593507 cites W2011543371 @default.
• W2080593507 cites W2018607339 @default.
• W2080593507 cites W2018671779 @default.
• W2080593507 cites W2023427658 @default.
• W2080593507 cites W2044887709 @default.
• W2080593507 cites W2048385227 @default.
• W2080593507 cites W2050300062 @default.
• W2080593507 cites W2060551076 @default.
• W2080593507 cites W2063916050 @default.
• W2080593507 cites W2077841029 @default.
• W2080593507 cites W2083730352 @default.
• W2080593507 cites W2086149372 @default.
• W2080593507 cites W2102085111 @default.
• W2080593507 cites W2109531556 @default.
• W2080593507 cites W2123509170 @default.
• W2080593507 cites W2124078079 @default.
• W2080593507 cites W2143619463 @default.
• W2080593507 cites W2151046897 @default.
• W2080593507 cites W2168414172 @default.
• W2080593507 cites W2168759510 @default.
• W2080593507 cites W2169752217 @default.
• W2080593507 doi "https://doi.org/10.1038/modpathol.3800942" @default.
• W2080593507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17660801" @default.
• W2080593507 hasPublicationYear "2007" @default.
• W2080593507 type Work @default.
• W2080593507 sameAs 2080593507 @default.
• W2080593507 citedByCount "56" @default.
• W2080593507 countsByYear W20805935072012 @default.
• W2080593507 countsByYear W20805935072013 @default.
• W2080593507 countsByYear W20805935072014 @default.
• W2080593507 countsByYear W20805935072015 @default.
• W2080593507 countsByYear W20805935072016 @default.
• W2080593507 countsByYear W20805935072017 @default.
• W2080593507 countsByYear W20805935072021 @default.
• W2080593507 crossrefType "journal-article" @default.
• W2080593507 hasAuthorship W2080593507A5002260928 @default.
• W2080593507 hasAuthorship W2080593507A5013049125 @default.
• W2080593507 hasAuthorship W2080593507A5015235892 @default.
• W2080593507 hasAuthorship W2080593507A5019186596 @default.
• W2080593507 hasAuthorship W2080593507A5030872551 @default.
• W2080593507 hasAuthorship W2080593507A5034471264 @default.
• W2080593507 hasAuthorship W2080593507A5036054973 @default.
• W2080593507 hasAuthorship W2080593507A5063732891 @default.
• W2080593507 hasAuthorship W2080593507A5075003658 @default.
• W2080593507 hasBestOaLocation W20805935071 @default.
• W2080593507 hasConcept C136302470 @default.
• W2080593507 hasConcept C142724271 @default.
• W2080593507 hasConcept C201750760 @default.
• W2080593507 hasConcept C28328180 @default.
• W2080593507 hasConcept C502942594 @default.
• W2080593507 hasConcept C55427017 @default.
• W2080593507 hasConcept C71924100 @default.
• W2080593507 hasConcept C86803240 @default.
• W2080593507 hasConcept C95444343 @default.
• W2080593507 hasConceptScore W2080593507C136302470 @default.
• W2080593507 hasConceptScore W2080593507C142724271 @default.
• W2080593507 hasConceptScore W2080593507C201750760 @default.
• W2080593507 hasConceptScore W2080593507C28328180 @default.
• W2080593507 hasConceptScore W2080593507C502942594 @default.
• W2080593507 hasConceptScore W2080593507C55427017 @default.
• W2080593507 hasConceptScore W2080593507C71924100 @default.
• W2080593507 hasConceptScore W2080593507C86803240 @default.
• W2080593507 hasConceptScore W2080593507C95444343 @default.
• W2080593507 hasIssue "10" @default.
• W2080593507 hasLocation W20805935071 @default.
• W2080593507 hasLocation W20805935072 @default.
• W2080593507 hasOpenAccess W2080593507 @default.
• W2080593507 hasPrimaryLocation W20805935071 @default.
• W2080593507 hasRelatedWork W1535695819 @default.
• W2080593507 hasRelatedWork W1976203623 @default.
• W2080593507 hasRelatedWork W1988352076 @default.
• W2080593507 hasRelatedWork W2009094422 @default.
• W2080593507 hasRelatedWork W2077494872 @default.
• W2080593507 hasRelatedWork W2581729773 @default.
• W2080593507 hasRelatedWork W2953327764 @default.
• W2080593507 hasRelatedWork W581145485 @default.
• W2080593507 hasRelatedWork W2187760030 @default.

• next