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- W2080595462 endingPage "965" @default.
- W2080595462 startingPage "938" @default.
- W2080595462 abstract "Recent studies demonstrate distinct changes in gene expression in cells exposed to a weak magnetic field (MF). Mechanisms of this phenomenon are not understood yet. We propose that proteins of the Cryptochrome family (CRY) are epigenetic sensors of the MF fluctuations, i.e., magnetic field-sensitive part of the epigenetic controlling mechanism. It was shown that CRY represses activity of the major circadian transcriptional complex CLOCK/BMAL1. At the same time, function of CRY, is apparently highly responsive to weak MF because of radical pairs that periodically arise in the functionally active site of CRY and mediate the radical pair mechanism of magnetoreception. It is known that the circadian complex influences function of every organ and tissue, including modulation of both NF-κB- and glucocorticoids- dependent signaling pathways. Thus, MFs and solar cycles-dependent geomagnetic field fluctuations are capable of altering expression of genes related to function of NF-κB, hormones and other biological regulators. Notably, NF-κB, along with its significant role in immune response, also participates in differential regulation of influenza virus RNA synthesis. Presented data suggests that in the case of global application (example—geomagnetic field), MF-mediated regulation may have epidemiological and other consequences." @default.
- W2080595462 created "2016-06-24" @default.
- W2080595462 creator A5010317276 @default.
- W2080595462 creator A5062640980 @default.
- W2080595462 date "2010-03-10" @default.
- W2080595462 modified "2023-09-24" @default.
- W2080595462 title "Mechanisms of Geomagnetic Field Influence on Gene Expression Using Influenza as a Model System: Basics of Physical Epidemiology" @default.
- W2080595462 cites W1482257856 @default.
- W2080595462 cites W1517851992 @default.
- W2080595462 cites W1520831419 @default.
- W2080595462 cites W1641228030 @default.
- W2080595462 cites W1967361236 @default.
- W2080595462 cites W1970901599 @default.
- W2080595462 cites W1975380397 @default.
- W2080595462 cites W1975784885 @default.
- W2080595462 cites W1975945099 @default.
- W2080595462 cites W1978306420 @default.
- W2080595462 cites W1980300702 @default.
- W2080595462 cites W1982857420 @default.
- W2080595462 cites W1992096593 @default.
- W2080595462 cites W1996081226 @default.
- W2080595462 cites W1997426777 @default.
- W2080595462 cites W1999931163 @default.
- W2080595462 cites W2007425694 @default.
- W2080595462 cites W2007534188 @default.
- W2080595462 cites W2007593843 @default.
- W2080595462 cites W2008174977 @default.
- W2080595462 cites W2018667227 @default.
- W2080595462 cites W2020231295 @default.
- W2080595462 cites W2023838799 @default.
- W2080595462 cites W2024795845 @default.
- W2080595462 cites W2025308802 @default.
- W2080595462 cites W2025333386 @default.
- W2080595462 cites W2031631158 @default.
- W2080595462 cites W2037367018 @default.
- W2080595462 cites W2041136510 @default.
- W2080595462 cites W2043422938 @default.
- W2080595462 cites W2045215883 @default.
- W2080595462 cites W2045870858 @default.
- W2080595462 cites W2050032978 @default.
- W2080595462 cites W2051101147 @default.
- W2080595462 cites W2051347752 @default.
- W2080595462 cites W2055526214 @default.
- W2080595462 cites W2056297672 @default.
- W2080595462 cites W2059474406 @default.
- W2080595462 cites W2074150439 @default.
- W2080595462 cites W2079467858 @default.
- W2080595462 cites W2086278609 @default.
- W2080595462 cites W2089172210 @default.
- W2080595462 cites W2091298524 @default.
- W2080595462 cites W2098617995 @default.
- W2080595462 cites W2099482445 @default.
- W2080595462 cites W2100384057 @default.
- W2080595462 cites W2105908230 @default.
- W2080595462 cites W2107243903 @default.
- W2080595462 cites W2108446653 @default.
- W2080595462 cites W2108577336 @default.
- W2080595462 cites W2111908151 @default.
- W2080595462 cites W2113166113 @default.
- W2080595462 cites W2113340624 @default.
- W2080595462 cites W2113909720 @default.
- W2080595462 cites W2117056576 @default.
- W2080595462 cites W2118661742 @default.
- W2080595462 cites W2123584715 @default.
- W2080595462 cites W2124709386 @default.
- W2080595462 cites W2126259061 @default.
- W2080595462 cites W2127010161 @default.
- W2080595462 cites W2128041888 @default.
- W2080595462 cites W2129313145 @default.
- W2080595462 cites W2138668594 @default.
- W2080595462 cites W2140442838 @default.
- W2080595462 cites W2142686640 @default.
- W2080595462 cites W2142928034 @default.
- W2080595462 cites W2147139331 @default.
- W2080595462 cites W2148078180 @default.
- W2080595462 cites W2148119611 @default.
- W2080595462 cites W2148650237 @default.
- W2080595462 cites W2149852653 @default.
- W2080595462 cites W2152750766 @default.
- W2080595462 cites W2154650914 @default.
- W2080595462 cites W2157303078 @default.
- W2080595462 cites W2168283452 @default.
- W2080595462 cites W2169922833 @default.
- W2080595462 cites W2178569391 @default.
- W2080595462 cites W2325755521 @default.
- W2080595462 cites W2399965169 @default.
- W2080595462 cites W2483889653 @default.
- W2080595462 cites W4206712909 @default.
- W2080595462 cites W4231612575 @default.
- W2080595462 cites W4297833967 @default.
- W2080595462 cites W4301647211 @default.
- W2080595462 cites W2024065085 @default.
- W2080595462 cites W2024494960 @default.
- W2080595462 doi "https://doi.org/10.3390/ijerph7030938" @default.
- W2080595462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2872305" @default.
- W2080595462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20617011" @default.
- W2080595462 hasPublicationYear "2010" @default.
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