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- W2080595517 abstract "Estrogen exerts many of its receptor-mediated neuroprotective functions through the activation of various intracellular signal transduction pathways including the mitogen activating protein kinase (MAPK), phospho inositol-3 kinase and protein kinase C pathways. Here we have used a hippocampal slice culture model of kainic acid-induced neurotoxic cell death to show that estrogen can protect against oxidative cell death. We have previously shown that MAPK and glycogen synthase kinase-3β (GSK-3β) are involved in the cell death/cell survival induced by kainic acid. In this model and other cellular and in vivo models we have shown that estrogen can also cause the phosphorylation and hence inactivation of GSK-3β, a known mediator of neuronal cell death. The effect of estrogen on GSK-3β activity is estrogen receptor mediated. Further, this estrogen/GSK-3β interaction may have functional consequences in cellular models of some key pathogenic pathways associated with Alzheimer’s disease. More specifically, estrogen affects the basal levels of tau phosphorylation at a site known to be phosphorylated by GSK-3β. Taken together, these data indicate a novel molecular and functional link between estrogen and GSK-3β and may have implications for estrogen receptor modulation as a target for the prevention of neurodegenerative disorders." @default.
- W2080595517 created "2016-06-24" @default.
- W2080595517 creator A5014696581 @default.
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- W2080595517 date "2005-01-01" @default.
- W2080595517 modified "2023-10-03" @default.
- W2080595517 title "Glycogen synthase kinase 3β links neuroprotection by 17β-estradiol to key Alzheimer processes" @default.
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- W2080595517 doi "https://doi.org/10.1016/j.neuroscience.2004.12.029" @default.
- W2080595517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15837120" @default.
- W2080595517 hasPublicationYear "2005" @default.
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