FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080596461> ?p ?o ?g. }

• W2080596461 endingPage "299" @default.
• W2080596461 startingPage "285" @default.
• W2080596461 abstract "Abstract A mouse homolog of the Drosophila pair-rule gene Odd Oz (Odz4) maps to the critical region of the l7Rn3 locus on mouse chromosome 7. Here we show that Odz4 is an excellent candidate for this allelic series because (1) it spans the entire critical region, (2) the phenotypes correlate with embryonic expression, (3) the complex genetic inheritance of the alleles is consistent with complex transcriptional regulation, and (4) one allele has a mutation in a conserved amino acid. Odz4 uses five alternate promoters that encode both secreted and membrane-bound proteins. Intragenic complementation of the l7Rn3 alleles is consistent with these multiple-protein isoforms. Further, the allelic series shows that Odz4 is required to establish the anterior-posterior axis of the gastrulating mouse embryo and is necessary later for mesoderm-derived tissues such as somites, heart, and skeleton. Sequencing of RT-PCR products from five of the six alleles reveals a nonconservative amino acid change in the l7Rn3m4 allele. This amino acid is important evolutionarily, as it is conserved to Drosophila. Together, our data indicate that Odz4 is mutated in the l7Rn3 allele series and performs roles in the mouse brain, heart, and embryonic patterning similar to those of its Drosophila counterpart." @default.
• W2080596461 created "2016-06-24" @default.
• W2080596461 creator A5005670691 @default.
• W2080596461 creator A5018439506 @default.
• W2080596461 creator A5033462949 @default.
• W2080596461 creator A5083706904 @default.
• W2080596461 date "2005-01-01" @default.
• W2080596461 modified "2023-10-09" @default.
• W2080596461 title "Mutation of l7Rn3 Shows That Odz4 Is Required for Mouse Gastrulation" @default.
• W2080596461 cites W1531234910 @default.
• W2080596461 cites W1679252210 @default.
• W2080596461 cites W1796219948 @default.
• W2080596461 cites W1832864842 @default.
• W2080596461 cites W1895345659 @default.
• W2080596461 cites W1964184435 @default.
• W2080596461 cites W1964832658 @default.
• W2080596461 cites W1968327773 @default.
• W2080596461 cites W1978456763 @default.
• W2080596461 cites W1980385101 @default.
• W2080596461 cites W1984802447 @default.
• W2080596461 cites W1987134899 @default.
• W2080596461 cites W1992865216 @default.
• W2080596461 cites W1998157671 @default.
• W2080596461 cites W2008311225 @default.
• W2080596461 cites W2008751067 @default.
• W2080596461 cites W2018158796 @default.
• W2080596461 cites W2022366078 @default.
• W2080596461 cites W2024643649 @default.
• W2080596461 cites W2027650800 @default.
• W2080596461 cites W2031383900 @default.
• W2080596461 cites W2039229290 @default.
• W2080596461 cites W2041407230 @default.
• W2080596461 cites W2064424062 @default.
• W2080596461 cites W2065975305 @default.
• W2080596461 cites W2069963126 @default.
• W2080596461 cites W2071297234 @default.
• W2080596461 cites W2090112933 @default.
• W2080596461 cites W2093200642 @default.
• W2080596461 cites W2103174149 @default.
• W2080596461 cites W2113281335 @default.
• W2080596461 cites W2117013211 @default.
• W2080596461 cites W2118971690 @default.
• W2080596461 cites W2120601026 @default.
• W2080596461 cites W2120903423 @default.
• W2080596461 cites W2121157101 @default.
• W2080596461 cites W2124070731 @default.
• W2080596461 cites W2133589858 @default.
• W2080596461 cites W2134581723 @default.
• W2080596461 cites W2136388918 @default.
• W2080596461 cites W2148013311 @default.
• W2080596461 cites W2151464048 @default.
• W2080596461 cites W2152352446 @default.
• W2080596461 cites W2168783124 @default.
• W2080596461 cites W2335117622 @default.
• W2080596461 cites W2576734941 @default.
• W2080596461 cites W4229799243 @default.
• W2080596461 cites W4239604467 @default.
• W2080596461 cites W4241879927 @default.
• W2080596461 doi "https://doi.org/10.1534/genetics.104.034967" @default.
• W2080596461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1448887" @default.
• W2080596461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15489520" @default.
• W2080596461 hasPublicationYear "2005" @default.
• W2080596461 type Work @default.
• W2080596461 sameAs 2080596461 @default.
• W2080596461 citedByCount "34" @default.
• W2080596461 countsByYear W20805964612012 @default.
• W2080596461 countsByYear W20805964612013 @default.
• W2080596461 countsByYear W20805964612014 @default.
• W2080596461 countsByYear W20805964612015 @default.
• W2080596461 countsByYear W20805964612017 @default.
• W2080596461 countsByYear W20805964612018 @default.
• W2080596461 countsByYear W20805964612019 @default.
• W2080596461 countsByYear W20805964612020 @default.
• W2080596461 countsByYear W20805964612022 @default.
• W2080596461 countsByYear W20805964612023 @default.
• W2080596461 crossrefType "journal-article" @default.
• W2080596461 hasAuthorship W2080596461A5005670691 @default.
• W2080596461 hasAuthorship W2080596461A5018439506 @default.
• W2080596461 hasAuthorship W2080596461A5033462949 @default.
• W2080596461 hasAuthorship W2080596461A5083706904 @default.
• W2080596461 hasBestOaLocation W20805964611 @default.
• W2080596461 hasConcept C104317684 @default.
• W2080596461 hasConcept C127716648 @default.
• W2080596461 hasConcept C129536746 @default.
• W2080596461 hasConcept C145103041 @default.
• W2080596461 hasConcept C180754005 @default.
• W2080596461 hasConcept C188082640 @default.
• W2080596461 hasConcept C2780915607 @default.
• W2080596461 hasConcept C53345823 @default.
• W2080596461 hasConcept C54355233 @default.
• W2080596461 hasConcept C84597430 @default.
• W2080596461 hasConcept C86803240 @default.
• W2080596461 hasConceptScore W2080596461C104317684 @default.
• W2080596461 hasConceptScore W2080596461C127716648 @default.
• W2080596461 hasConceptScore W2080596461C129536746 @default.
• W2080596461 hasConceptScore W2080596461C145103041 @default.
• W2080596461 hasConceptScore W2080596461C180754005 @default.
• W2080596461 hasConceptScore W2080596461C188082640 @default.

• next