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- W2080597613 abstract "1. The effects of melatonin on the contractile responses to 5-hydroxytryptamine (5-HT), norepinephrine (NE), angiotensin-1 (AT-1) and potassium were determined on the rabbit isolated aorta, iliac and renal arteries. 2. Melatonin, at 10−4 or 10−3 M inhibited the response to 5-HT in the aorta, iliac and renal arteries. 3. Melatonin, at 10−3 M, had a negligible effect on the responses to NE and AT-1 in all preparations used. 4. The potassium-induced contraction of all 3 preparations used was slightly inhibited by only the high concentration of melatonin (10−3 M). 5. In a Ca+-free medium with EGTA (0.1 mM), the residual response to 5-HT (10−5 or 10−4 M) were inhibited by melatonin (10−4 or 10−3 M) in all preparations used. 6. In a Ca2+-free medium with EGTA (0.01 mM), nifedipine (10−6M) and 5-HT (5 × 10−7 M), application of Ca2+ (2 mM) resulted in a tonic contraction, related to receptor operated channels, of all preparations. This Ca2+ dependent, nifedipine insensitive contraction was markedly inhibited or abolished by melatonin at 10−5 and 10−4 M. 7. These results demonstrated that melatonin had a generally greater inhibitory effect on the response to 5-HT than those to NE, AT-1 and potassium in vascular smooth muscles. Also the results suggest that action of melatonin on the 5-HT induced contraction is more related to interference with Ca2+ influx through receptor operated channels than release of intracellular Ca2+ from the store site." @default.
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- W2080597613 date "1986-01-01" @default.
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- W2080597613 title "The inhibitory action of melatonin on the contractile response to 5-hydroxytryptamine in various isolated vascular smooth muscles" @default.
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- W2080597613 doi "https://doi.org/10.1016/0306-3623(86)90092-3" @default.
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