Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080597913> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2080597913 endingPage "S229" @default.
- W2080597913 startingPage "S229" @default.
- W2080597913 abstract "Aldehyde dehydrogenases (ALDHs) are a family of enzymes involved in detoxifying aldehydes. Previously, we reported that an ALDH inhibitor, disulfiram caused bone loss in rats and among ALDHs, osteoblast expressed only ALDH2. Loss-of-function mutation in ALDH2 gene is reported to cause bone loss in humans which suggested its importance in skeletal homeostasis. We thus studied whether activating ALDH2 by N-(1, 3-benzodioxol-5-ylmethyl)-2, 6-dichlorobenzamide (alda-1) had osteogenic effect. We found that alda-1 increased and acetaldehyde decreased the differentiation of rat primary osteoblasts and expressions of ALDH2 and bone morphogenetic protein-2 (BMP-2). Silencing ALDH2 in osteoblasts abolished the alda-1 effects. Further, alda-1 attenuated the acetaldehyde-induced lipid-peroxidation and oxidative stress. BMP-2 is essential for bone regeneration and alda-1 increased its expression in osteoblasts. We then showed that alda-1 (40 mg/kg dose) augmented bone regeneration at the fracture site with concomitant increase in BMP-2 protein compared with control. The osteogenic dose (40 mg/kg) of alda-1 attained a bone marrow concentration that was stimulatory for osteoblast differentiation, suggesting that the tissue concentration of alda-1 matched its pharmacologic effect. In addition, alda-1 promoted modeling-directed bone growth and peak bone mass achievement, and increased bone mass in adult rats which reiterated its osteogenic effect. In osteopenic ovariectomized (OVX) rats, alda-1 reversed trabecular osteopenia with attendant increase in serum osteogenic marker (procollagen type I N-terminal peptide) and decrease in oxidative stress. Alda-1 has no effect on liver and kidney function. We conclude that activating ALDH2 by alda-1 had an osteoanabolic effect involving increased osteoblastic BMP-2 production and decreased OVX-induced oxidative stress." @default.
- W2080597913 created "2016-06-24" @default.
- W2080597913 creator A5007246405 @default.
- W2080597913 creator A5022810670 @default.
- W2080597913 creator A5029682979 @default.
- W2080597913 creator A5050391228 @default.
- W2080597913 creator A5055600741 @default.
- W2080597913 creator A5084037014 @default.
- W2080597913 date "2011-05-01" @default.
- W2080597913 modified "2023-10-16" @default.
- W2080597913 title "PTH 1–84 and bone turnover markers in severe post-menopausal osteoporosis" @default.
- W2080597913 doi "https://doi.org/10.1016/j.bone.2011.03.543" @default.
- W2080597913 hasPublicationYear "2011" @default.
- W2080597913 type Work @default.
- W2080597913 sameAs 2080597913 @default.
- W2080597913 citedByCount "0" @default.
- W2080597913 crossrefType "journal-article" @default.
- W2080597913 hasAuthorship W2080597913A5007246405 @default.
- W2080597913 hasAuthorship W2080597913A5022810670 @default.
- W2080597913 hasAuthorship W2080597913A5029682979 @default.
- W2080597913 hasAuthorship W2080597913A5050391228 @default.
- W2080597913 hasAuthorship W2080597913A5055600741 @default.
- W2080597913 hasAuthorship W2080597913A5084037014 @default.
- W2080597913 hasConcept C126322002 @default.
- W2080597913 hasConcept C134018914 @default.
- W2080597913 hasConcept C170033053 @default.
- W2080597913 hasConcept C181199279 @default.
- W2080597913 hasConcept C185592680 @default.
- W2080597913 hasConcept C202751555 @default.
- W2080597913 hasConcept C25747580 @default.
- W2080597913 hasConcept C2776541429 @default.
- W2080597913 hasConcept C2777595113 @default.
- W2080597913 hasConcept C2778260815 @default.
- W2080597913 hasConcept C2780161600 @default.
- W2080597913 hasConcept C3175096 @default.
- W2080597913 hasConcept C55493867 @default.
- W2080597913 hasConcept C71924100 @default.
- W2080597913 hasConceptScore W2080597913C126322002 @default.
- W2080597913 hasConceptScore W2080597913C134018914 @default.
- W2080597913 hasConceptScore W2080597913C170033053 @default.
- W2080597913 hasConceptScore W2080597913C181199279 @default.
- W2080597913 hasConceptScore W2080597913C185592680 @default.
- W2080597913 hasConceptScore W2080597913C202751555 @default.
- W2080597913 hasConceptScore W2080597913C25747580 @default.
- W2080597913 hasConceptScore W2080597913C2776541429 @default.
- W2080597913 hasConceptScore W2080597913C2777595113 @default.
- W2080597913 hasConceptScore W2080597913C2778260815 @default.
- W2080597913 hasConceptScore W2080597913C2780161600 @default.
- W2080597913 hasConceptScore W2080597913C3175096 @default.
- W2080597913 hasConceptScore W2080597913C55493867 @default.
- W2080597913 hasConceptScore W2080597913C71924100 @default.
- W2080597913 hasLocation W20805979131 @default.
- W2080597913 hasOpenAccess W2080597913 @default.
- W2080597913 hasPrimaryLocation W20805979131 @default.
- W2080597913 hasRelatedWork W1132239602 @default.
- W2080597913 hasRelatedWork W1916367101 @default.
- W2080597913 hasRelatedWork W2035881163 @default.
- W2080597913 hasRelatedWork W2059882957 @default.
- W2080597913 hasRelatedWork W2067793168 @default.
- W2080597913 hasRelatedWork W2154807729 @default.
- W2080597913 hasRelatedWork W2253136179 @default.
- W2080597913 hasRelatedWork W2355320897 @default.
- W2080597913 hasRelatedWork W2992633709 @default.
- W2080597913 hasRelatedWork W86840971 @default.
- W2080597913 hasVolume "48" @default.
- W2080597913 isParatext "false" @default.
- W2080597913 isRetracted "false" @default.
- W2080597913 magId "2080597913" @default.
- W2080597913 workType "article" @default.