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- W2080598436 abstract "Recently we found novel zaragozic acids (ZAs), F-10863A (zaragozic acid D3, ZAD3), B, C and D in the culture broth of the fungus Mollisia sp. SANK 10294 as potent inhibitors of squalene synthase. There are several other enzymes that use farnesylpyrophosphate as their substrate. Among them we chose farnesyl-protein transferase and examined whether ZAD3 and F-10863B inhibit this enzyme's activity. ZAD3 and F-10863B inhibited farnesyl-protein transferase with IC50 values of 0.60 and 3.7 microM, respectively. They also inhibited geranylgeranyl-protein transferase at similar concentrations. In addition, they exhibited potent antifungal activity." @default.
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- W2080598436 date "1998-01-01" @default.
- W2080598436 modified "2023-10-14" @default.
- W2080598436 title "Inhibitory Activity to Protein Prenylation and Antifungal Activity of Zaragozic Acid D3, a Potent Inhibitor of Squalene Synthase Produced by the Fungus, Mollisia sp. SANK 10294." @default.
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- W2080598436 doi "https://doi.org/10.7164/antibiotics.51.428" @default.
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