Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080598828> ?p ?o ?g. }
- W2080598828 endingPage "934" @default.
- W2080598828 startingPage "925" @default.
- W2080598828 abstract "Ind-Gsh-type homeodomain proteins are critical to patterning of intermediate domains in the developing CNS; yet, the molecular basis for the activities of these homeodomain proteins is not well understood. Here we identify domains within the Ind protein that are responsible for transcriptional repression, as well as those required for its interaction with the co-repressor, Groucho. To do this, we utilized a combination of chimeric transient transfection assays, co-immunoprecipitation and in vivo expression assays. We show that Ind's candidate Eh1 domain is essential to the embryonic repression activity of this protein, and that Groucho interacts with Ind via this domain. However, when activity is assayed in transient transfection assays using Ind-Gal4 DNA binding domain chimeras to determine domain activity, the repression activity of the Eh1 domain is minimal. This result is similar to previous results on the transcription factors, Vnd and Engrailed. Furthermore, the Eh1 domain is necessary, but not sufficient, for binding to Groucho; the C terminus of Ind, including the homeodomain also affects the interaction with this co-repressor in co-immunoprecipitations. Finally, we show that aspects of the cross-repressive activities of Ind/Gsh2-Ey/Pax6 are evolutionarily conserved. Taken together, these results point to conserved mechanisms used by Gsh/Ind-type homeodomain protein in regulating the expression of target genes." @default.
- W2080598828 created "2016-06-24" @default.
- W2080598828 creator A5035569033 @default.
- W2080598828 creator A5078858200 @default.
- W2080598828 creator A5088327236 @default.
- W2080598828 date "2007-11-01" @default.
- W2080598828 modified "2023-10-10" @default.
- W2080598828 title "Conserved properties of the Drosophila homeodomain protein, Ind" @default.
- W2080598828 cites W156202311 @default.
- W2080598828 cites W1589246521 @default.
- W2080598828 cites W1835728047 @default.
- W2080598828 cites W188998665 @default.
- W2080598828 cites W1892276981 @default.
- W2080598828 cites W1943658588 @default.
- W2080598828 cites W1969803167 @default.
- W2080598828 cites W1974215719 @default.
- W2080598828 cites W1979518502 @default.
- W2080598828 cites W1986457767 @default.
- W2080598828 cites W1987366641 @default.
- W2080598828 cites W1995856607 @default.
- W2080598828 cites W1997301708 @default.
- W2080598828 cites W2000306719 @default.
- W2080598828 cites W2004257326 @default.
- W2080598828 cites W2004616894 @default.
- W2080598828 cites W2011297031 @default.
- W2080598828 cites W2012092107 @default.
- W2080598828 cites W2014479208 @default.
- W2080598828 cites W2016916478 @default.
- W2080598828 cites W2018168999 @default.
- W2080598828 cites W2024669825 @default.
- W2080598828 cites W2034452566 @default.
- W2080598828 cites W2039371575 @default.
- W2080598828 cites W2050926725 @default.
- W2080598828 cites W2057927081 @default.
- W2080598828 cites W2058039243 @default.
- W2080598828 cites W2076499613 @default.
- W2080598828 cites W2078694814 @default.
- W2080598828 cites W2095145065 @default.
- W2080598828 cites W2097065859 @default.
- W2080598828 cites W2101630525 @default.
- W2080598828 cites W2102589238 @default.
- W2080598828 cites W2103080800 @default.
- W2080598828 cites W2108663844 @default.
- W2080598828 cites W2109899567 @default.
- W2080598828 cites W2110643873 @default.
- W2080598828 cites W2111290586 @default.
- W2080598828 cites W2112066508 @default.
- W2080598828 cites W2120933894 @default.
- W2080598828 cites W2122199698 @default.
- W2080598828 cites W2123933036 @default.
- W2080598828 cites W2127262898 @default.
- W2080598828 cites W2128381684 @default.
- W2080598828 cites W2128886230 @default.
- W2080598828 cites W2133488136 @default.
- W2080598828 cites W2141671204 @default.
- W2080598828 cites W2144825743 @default.
- W2080598828 cites W2149925209 @default.
- W2080598828 cites W2155186791 @default.
- W2080598828 cites W2161795407 @default.
- W2080598828 cites W2169537162 @default.
- W2080598828 cites W2171206652 @default.
- W2080598828 cites W2188679571 @default.
- W2080598828 cites W2254185323 @default.
- W2080598828 doi "https://doi.org/10.1016/j.mod.2007.08.001" @default.
- W2080598828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17900877" @default.
- W2080598828 hasPublicationYear "2007" @default.
- W2080598828 type Work @default.
- W2080598828 sameAs 2080598828 @default.
- W2080598828 citedByCount "16" @default.
- W2080598828 countsByYear W20805988282012 @default.
- W2080598828 countsByYear W20805988282014 @default.
- W2080598828 countsByYear W20805988282020 @default.
- W2080598828 countsByYear W20805988282023 @default.
- W2080598828 crossrefType "journal-article" @default.
- W2080598828 hasAuthorship W2080598828A5035569033 @default.
- W2080598828 hasAuthorship W2080598828A5078858200 @default.
- W2080598828 hasAuthorship W2080598828A5088327236 @default.
- W2080598828 hasConcept C104317684 @default.
- W2080598828 hasConcept C11804247 @default.
- W2080598828 hasConcept C121587040 @default.
- W2080598828 hasConcept C123894998 @default.
- W2080598828 hasConcept C144292202 @default.
- W2080598828 hasConcept C150194340 @default.
- W2080598828 hasConcept C158448853 @default.
- W2080598828 hasConcept C174851938 @default.
- W2080598828 hasConcept C186310378 @default.
- W2080598828 hasConcept C40767141 @default.
- W2080598828 hasConcept C54355233 @default.
- W2080598828 hasConcept C64632358 @default.
- W2080598828 hasConcept C71829478 @default.
- W2080598828 hasConcept C86339819 @default.
- W2080598828 hasConcept C86803240 @default.
- W2080598828 hasConcept C94966510 @default.
- W2080598828 hasConcept C95444343 @default.
- W2080598828 hasConceptScore W2080598828C104317684 @default.
- W2080598828 hasConceptScore W2080598828C11804247 @default.
- W2080598828 hasConceptScore W2080598828C121587040 @default.
- W2080598828 hasConceptScore W2080598828C123894998 @default.