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• W2080607046 endingPage "4834" @default.
• W2080607046 startingPage "4823" @default.
• W2080607046 abstract "Forecasting disease susceptibility requires detection of maladaptive signatures prior to onset of overt symptoms. A case-in-point are cardiac ATP-sensitive K+ (KATP) channelopathies, for which the substrate underlying disease vulnerability remains to be identified. Resolving molecular pathobiology, even for single genetic defects, mandates a systems platform to reliably diagnose disease predisposition. High-throughput proteomic analysis was here integrated with network biology to decode consequences of Kir6.2 KATP channel pore deletion. Differential two-dimensional gel electrophoresis reproducibly resolved >800 protein species from hearts of asymptomatic wild-type and Kir6.2-knockout counterparts. KATP channel ablation remodeled the cardiac proteome, significantly altering 71 protein spots, from which 102 unique identities were assigned following hybrid linear ion trap quadrupole-Orbitrap tandem mass spectrometry. Ontological annotation stratified the KATP channel-dependent protein cohort into a predominant bioenergetic module (63 resolved identities), with additional focused sets representing signaling molecules (6), oxidoreductases (8), chaperones (6), and proteins involved in catabolism (6), cytostructure (8), and transcription and translation (5). Protein interaction mapping, in conjunction with expression level changes, localized a KATP channel-associated subproteome within a nonstochastic scale-free network. Global assessment of the KATP channel deficient environment verified the primary impact on metabolic pathways and revealed overrepresentation of markers associated with cardiovascular disease. Experimental imposition of graded stress precipitated exaggerated structural and functional myocardial defects in the Kir6.2-knockout, decreasing survivorship and validating the forecast of disease susceptibility. Proteomic cartography thus provides an integral view of molecular remodeling in the heart induced by KATP channel deletion, establishing a systems approach that predicts outcome at a presymptomatic stage." @default.
• W2080607046 created "2016-06-24" @default.
• W2080607046 creator A5005425358 @default.
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• W2080607046 creator A5047902810 @default.
• W2080607046 date "2009-09-04" @default.
• W2080607046 modified "2023-10-06" @default.
• W2080607046 title "ATP-Sensitive K⁺ Channel Knockout Induces Cardiac Proteome Remodeling Predictive of Heart Disease Susceptibility" @default.
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• W2080607046 doi "https://doi.org/10.1021/pr900561g" @default.
• W2080607046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2818626" @default.
• W2080607046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19673485" @default.
• W2080607046 hasPublicationYear "2009" @default.
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