FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080607777> ?p ?o ?g. }

• W2080607777 endingPage "8677" @default.
• W2080607777 startingPage "8670" @default.
• W2080607777 abstract "Abstract Aromatase inhibitors are important drugs to treat estrogen receptor α (ERα)–positive postmenopausal breast cancer patients. However, development of resistance to aromatase inhibitors has been observed. We examined whether the heat shock protein 90 (HSP90) inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) can inhibit the growth of aromatase inhibitor–resistant breast cancers and the mechanisms by which 17-DMAG affects proliferation. Aromatase inhibitor–responsive MCF-7aro and aromatase inhibitor–resistant LTEDaro breast epithelial cells were used in this study. We observed that 17-DMAG inhibited proliferation in both MCF-7aro and LTEDaro cells in a dose-dependent manner. 17-DMAG induced apoptosis and G2 cell cycle arrest in both cell lines. Although inhibition of HSP90 decreased the levels of ERα, the ERα transcriptional activity was not affected when cells were treated with 17-DMAG together with estradiol. Moreover, detailed mechanistic studies suggested that 17-DMAG inhibits cell growth via degradation of HSP90 client proteins AKT and HER2. Collectively, results from this study provide data to support that HSP90 inhibitors may be an effective therapy to treat aromatase inhibitor–resistant breast cancers and that improved efficacy can be achieved by combined use of a HSP90 inhibitor and an AKT inhibitor. [Cancer Res 2009;69(22):8670–7]" @default.
• W2080607777 created "2016-06-24" @default.
• W2080607777 creator A5064649529 @default.
• W2080607777 creator A5081284499 @default.
• W2080607777 date "2009-11-11" @default.
• W2080607777 modified "2023-10-16" @default.
• W2080607777 title "Heat Shock Protein 90 Inhibitors: New Mode of Therapy to Overcome Endocrine Resistance" @default.
• W2080607777 cites W1942214720 @default.
• W2080607777 cites W1964826325 @default.
• W2080607777 cites W1974024530 @default.
• W2080607777 cites W1977254575 @default.
• W2080607777 cites W1997006452 @default.
• W2080607777 cites W2000929246 @default.
• W2080607777 cites W2002044132 @default.
• W2080607777 cites W2006148642 @default.
• W2080607777 cites W2014922787 @default.
• W2080607777 cites W2024306318 @default.
• W2080607777 cites W2026389696 @default.
• W2080607777 cites W2045494872 @default.
• W2080607777 cites W2053503219 @default.
• W2080607777 cites W2058601513 @default.
• W2080607777 cites W206480088 @default.
• W2080607777 cites W2072787342 @default.
• W2080607777 cites W2077945404 @default.
• W2080607777 cites W2078558213 @default.
• W2080607777 cites W2082390299 @default.
• W2080607777 cites W2083497989 @default.
• W2080607777 cites W2094665743 @default.
• W2080607777 cites W2096400548 @default.
• W2080607777 cites W2097349743 @default.
• W2080607777 cites W2097767970 @default.
• W2080607777 cites W2107831273 @default.
• W2080607777 cites W2115974767 @default.
• W2080607777 cites W2119999468 @default.
• W2080607777 cites W2123056940 @default.
• W2080607777 cites W2124590690 @default.
• W2080607777 cites W2134001292 @default.
• W2080607777 cites W2137035181 @default.
• W2080607777 cites W2137417707 @default.
• W2080607777 cites W2145819414 @default.
• W2080607777 cites W2147114673 @default.
• W2080607777 cites W2169988894 @default.
• W2080607777 cites W2216094174 @default.
• W2080607777 cites W2356498392 @default.
• W2080607777 cites W8163034 @default.
• W2080607777 doi "https://doi.org/10.1158/0008-5472.can-09-1259" @default.
• W2080607777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2784253" @default.
• W2080607777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19861537" @default.
• W2080607777 hasPublicationYear "2009" @default.
• W2080607777 type Work @default.
• W2080607777 sameAs 2080607777 @default.
• W2080607777 citedByCount "33" @default.
• W2080607777 countsByYear W20806077772012 @default.
• W2080607777 countsByYear W20806077772013 @default.
• W2080607777 countsByYear W20806077772014 @default.
• W2080607777 countsByYear W20806077772015 @default.
• W2080607777 countsByYear W20806077772016 @default.
• W2080607777 countsByYear W20806077772018 @default.
• W2080607777 countsByYear W20806077772021 @default.
• W2080607777 crossrefType "journal-article" @default.
• W2080607777 hasAuthorship W2080607777A5064649529 @default.
• W2080607777 hasAuthorship W2080607777A5081284499 @default.
• W2080607777 hasBestOaLocation W20806077771 @default.
• W2080607777 hasConcept C104317684 @default.
• W2080607777 hasConcept C121608353 @default.
• W2080607777 hasConcept C126322002 @default.
• W2080607777 hasConcept C134018914 @default.
• W2080607777 hasConcept C185592680 @default.
• W2080607777 hasConcept C190283241 @default.
• W2080607777 hasConcept C205260736 @default.
• W2080607777 hasConcept C2775932338 @default.
• W2080607777 hasConcept C2776166826 @default.
• W2080607777 hasConcept C2777560012 @default.
• W2080607777 hasConcept C2778504769 @default.
• W2080607777 hasConcept C502942594 @default.
• W2080607777 hasConcept C530470458 @default.
• W2080607777 hasConcept C55493867 @default.
• W2080607777 hasConcept C62112901 @default.
• W2080607777 hasConcept C71924100 @default.
• W2080607777 hasConcept C75217442 @default.
• W2080607777 hasConcept C84606932 @default.
• W2080607777 hasConcept C86803240 @default.
• W2080607777 hasConcept C98274493 @default.
• W2080607777 hasConceptScore W2080607777C104317684 @default.
• W2080607777 hasConceptScore W2080607777C121608353 @default.
• W2080607777 hasConceptScore W2080607777C126322002 @default.
• W2080607777 hasConceptScore W2080607777C134018914 @default.
• W2080607777 hasConceptScore W2080607777C185592680 @default.
• W2080607777 hasConceptScore W2080607777C190283241 @default.
• W2080607777 hasConceptScore W2080607777C205260736 @default.
• W2080607777 hasConceptScore W2080607777C2775932338 @default.
• W2080607777 hasConceptScore W2080607777C2776166826 @default.
• W2080607777 hasConceptScore W2080607777C2777560012 @default.
• W2080607777 hasConceptScore W2080607777C2778504769 @default.
• W2080607777 hasConceptScore W2080607777C502942594 @default.
• W2080607777 hasConceptScore W2080607777C530470458 @default.
• W2080607777 hasConceptScore W2080607777C55493867 @default.
• W2080607777 hasConceptScore W2080607777C62112901 @default.

• next