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- W2080610151 abstract "We report an efficient and convergent synthesis of a series of oligosaccharides comprised of the malaria GPI glycan (2a), a promising anti-malaria vaccine candidate currently in preclinical trials and several related oligosaccharide sequences (3-8) that are possible biosynthetic precursors of the malarial GPI. A flexible synthetic strategy is disclosed that relies on a late-stage coupling between oligomannosides of varying length and pseudo-disaccharide glycosyl acceptor 11 to readily access various malarial GPI structures. Phosphorylation was accomplished by mild and efficient H-phosphonate chemistry before the final deprotection was carried out by using sodium in ammonia. The direct connection of a thiol group via a phosphate diester linkage to the inositol moiety provides a handle for easy conjugation of the GPI glycan to carrier proteins, immobilization on carbohydrate microarrays and photo-affinity labels identification. These synthetic oligosaccharides will serve as molecular probes." @default.
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- W2080610151 date "2005-04-05" @default.
- W2080610151 modified "2023-10-11" @default.
- W2080610151 title "Assembly of a Series of Malarial Glycosylphosphatidylinositol Anchor Oligosaccharides" @default.
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- W2080610151 doi "https://doi.org/10.1002/chem.200400934" @default.
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