FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W208061041> ?p ?o ?g. }

• W208061041 endingPage "674" @default.
• W208061041 startingPage "670" @default.
• W208061041 abstract "OBJECTIVE To explore the inflammatory reactions, endothelin level and carotid sinus nerve (CSN) afferent activity of carotid body (CB) after intermittent hypoxia/reoxygenation (IH/ROX) exposure of various frequencies in rabbits. METHODS Forty-nine male adult New Zealand white rabbits (2.5-3.0 kg) were separated into 7 groups (n = 7 each). After anesthetization, the right carotid artery and CSN were cleared of surrounding tissues without touching the right CB and the left carotid region. The CSN was unenveloped to partially expose the myelin sheath, and electrodes were placed to the single chemoreceptor bundle of the CSN, with CSN afferent activity carefully monitored and recorded. Then the right common carotid artery was exposed, cannulated to distal part and its proximal part was ligated. Preparations were challenged by changing the PO2 of the gas mixture equilibrating the perfusate. Alternatively perfusion (2 ml/min) of equilibrated perfusate bubbled with normoxia or hypoxia gas mixtures formed IH/ROX cycles in right carotid common artery, simulating the pattern of hypoxic episodes seen in obstructive sleep apnea, or with continuously perfusing hypoxia perfusate to form continuous hypoxia (CH) modes. Groups were defined with different frequencies, and groups were: intermittent normoxia group (IN group) (21% O2, 15 s; 21% O2, 1 min 45 s), 10/hr group (5% O2, 15 s; 21% O2, 5 min 45 s), 30/hr group (5% O2, 15 s; 21% O2, 1 min 45 s), 50/hr group (5% O2, 15 s; 21% O2, 57 s), 60/hr group (5% O2, 15 s; 21% O2, 45 s) and 90/hr group (5% O2, 15 s; 21% O2, 25 s). All the above groups were exposed to 60 treatment cycles; continuous hypoxia group (CH group), IN for 1 h 45 min and then 5% O2 for 15 min. After exposure and 30 min of static placing, CSN afferent frequencies (Charge F) were recorded from chemoreceptor bundles, and the right CB was cleared of surrounding tissues and harvested. Interleukin-6 (IL-6), endothelin-1 (ET-1), hypoxia-inducible factor-1 (HIF-1), and vascular endothelial growth factor (VEGF) concentrations of the CB lysate were measured with enzyme linked immuno sorbent assay (ELISA) kits and standardized. Data were analyzed with SPSS 12.0 software package; and after one way analysis of variance (ANOVA) for whole difference, Tamhane's T2 was used for post hoc analysis. RESULTS IL-6, ET-1 and Charge F increased but then decreased with increasing IH frequencies (F = 25,601.39, 2390.48, 6945.84, all P values 0.05). HIF-1 levels elevated gradually (F = 5241.10, P < 0.01) with increasing exposure frequencies, and the CH group had the highest value (all P values < 0.01). VEGF level in CH group was the highest in all groups (all P values < 0.01). CONCLUSIONS After IH/ROX exposure, afferent activity of CB CSN increases, which significantly correlates with inflammation and vasomotor mechanism of CB. CB inflammation comes not from IH phases but from ROX phases. Increased CB CSN activity results in elevated SNA tension, which plays a key role in the pathogenesis of systemic hypertension. This procedure influenced by IH/ROX frequencies. CH for 15 min causes no definitely damages. However, HIF-1 and VEGF can be considered as members of adaptive pathway during IH/ROX exposure." @default.
• W208061041 created "2016-06-24" @default.
• W208061041 creator A5002625267 @default.
• W208061041 creator A5003313122 @default.
• W208061041 creator A5003744538 @default.
• W208061041 creator A5006404930 @default.
• W208061041 creator A5008037802 @default.
• W208061041 creator A5024648164 @default.
• W208061041 creator A5043296622 @default.
• W208061041 creator A5045492083 @default.
• W208061041 creator A5048848655 @default.
• W208061041 date "2008-09-01" @default.
• W208061041 modified "2023-09-23" @default.
• W208061041 title "Carotid body inflammation and carotid sinus nerve afferent activity after intermittent hypoxia exposure of various frequencies in rabbits" @default.
• W208061041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19080567" @default.
• W208061041 hasPublicationYear "2008" @default.
• W208061041 type Work @default.
• W208061041 sameAs 208061041 @default.
• W208061041 citedByCount "1" @default.
• W208061041 countsByYear W2080610412022 @default.
• W208061041 crossrefType "journal-article" @default.
• W208061041 hasAuthorship W208061041A5002625267 @default.
• W208061041 hasAuthorship W208061041A5003313122 @default.
• W208061041 hasAuthorship W208061041A5003744538 @default.
• W208061041 hasAuthorship W208061041A5006404930 @default.
• W208061041 hasAuthorship W208061041A5008037802 @default.
• W208061041 hasAuthorship W208061041A5024648164 @default.
• W208061041 hasAuthorship W208061041A5043296622 @default.
• W208061041 hasAuthorship W208061041A5045492083 @default.
• W208061041 hasAuthorship W208061041A5048848655 @default.
• W208061041 hasConcept C103247709 @default.
• W208061041 hasConcept C105702510 @default.
• W208061041 hasConcept C126322002 @default.
• W208061041 hasConcept C134018914 @default.
• W208061041 hasConcept C146957229 @default.
• W208061041 hasConcept C170493617 @default.
• W208061041 hasConcept C178790620 @default.
• W208061041 hasConcept C185592680 @default.
• W208061041 hasConcept C2778113364 @default.
• W208061041 hasConcept C2778774071 @default.
• W208061041 hasConcept C2781064879 @default.
• W208061041 hasConcept C2987047532 @default.
• W208061041 hasConcept C42219234 @default.
• W208061041 hasConcept C540031477 @default.
• W208061041 hasConcept C71924100 @default.
• W208061041 hasConcept C7836513 @default.
• W208061041 hasConcept C83974742 @default.
• W208061041 hasConceptScore W208061041C103247709 @default.
• W208061041 hasConceptScore W208061041C105702510 @default.
• W208061041 hasConceptScore W208061041C126322002 @default.
• W208061041 hasConceptScore W208061041C134018914 @default.
• W208061041 hasConceptScore W208061041C146957229 @default.
• W208061041 hasConceptScore W208061041C170493617 @default.
• W208061041 hasConceptScore W208061041C178790620 @default.
• W208061041 hasConceptScore W208061041C185592680 @default.
• W208061041 hasConceptScore W208061041C2778113364 @default.
• W208061041 hasConceptScore W208061041C2778774071 @default.
• W208061041 hasConceptScore W208061041C2781064879 @default.
• W208061041 hasConceptScore W208061041C2987047532 @default.
• W208061041 hasConceptScore W208061041C42219234 @default.
• W208061041 hasConceptScore W208061041C540031477 @default.
• W208061041 hasConceptScore W208061041C71924100 @default.
• W208061041 hasConceptScore W208061041C7836513 @default.
• W208061041 hasConceptScore W208061041C83974742 @default.
• W208061041 hasIssue "9" @default.
• W208061041 hasLocation W2080610411 @default.
• W208061041 hasLocation W2080610412 @default.
• W208061041 hasOpenAccess W208061041 @default.
• W208061041 hasPrimaryLocation W2080610411 @default.
• W208061041 hasRelatedWork W1214885789 @default.
• W208061041 hasRelatedWork W184310203 @default.
• W208061041 hasRelatedWork W2015812446 @default.
• W208061041 hasRelatedWork W2063617798 @default.
• W208061041 hasRelatedWork W2068943637 @default.
• W208061041 hasRelatedWork W2077283298 @default.
• W208061041 hasRelatedWork W2083116557 @default.
• W208061041 hasRelatedWork W2086508505 @default.
• W208061041 hasRelatedWork W2100333501 @default.
• W208061041 hasRelatedWork W2143681492 @default.
• W208061041 hasRelatedWork W2302765339 @default.
• W208061041 hasRelatedWork W2343571464 @default.
• W208061041 hasRelatedWork W2344234782 @default.
• W208061041 hasRelatedWork W2398590279 @default.
• W208061041 hasRelatedWork W2410899530 @default.
• W208061041 hasRelatedWork W2949491287 @default.
• W208061041 hasRelatedWork W3025091368 @default.
• W208061041 hasRelatedWork W3112897536 @default.
• W208061041 hasRelatedWork W38361201 @default.
• W208061041 hasRelatedWork W2259673030 @default.
• W208061041 hasVolume "31" @default.
• W208061041 isParatext "false" @default.
• W208061041 isRetracted "false" @default.
• W208061041 magId "208061041" @default.
• W208061041 workType "article" @default.