FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080614092> ?p ?o ?g. }

• W2080614092 endingPage "38" @default.
• W2080614092 startingPage "34" @default.
• W2080614092 abstract "Dietary choline is an important modulator of gene expression (via epigenetic marks) and of DNA integrity. Choline was discovered to be an essential nutrient for some humans approximately one decade ago. This requirement is diminished in young women because estrogen drives endogenous synthesis of phosphatidylcholine, from which choline can be derived. Almost half of women have a single nucleotide polymorphism that abrogates estrogen-induction of endogenous synthesis, and these women require dietary choline just as do men. In the US, dietary intake of choline is marginal. Choline deficiency in people is associated with liver and muscle dysfunction and damage, with apoptosis, and with increased DNA strand breaks. Several mechanisms explain these modifications to DNA. Choline deficiency increases leakage of reactive oxygen species from mitochondria consequent to altered mitochondrial membrane composition and enhanced fatty acid oxidation. Choline deficiency impairs folate metabolism, resulting in decreased thymidylate synthesis and increased uracil misincorporation into DNA, with strand breaks resulting during error-prone repair attempts. Choline deficiency alters DNA methylation, which alters gene expression for critical genes involved in DNA mismatch repair, resulting in increased mutation rates. Any dietary deficiency which increases mutation rates should be associated with increased risk of cancers, and this is the case for choline deficiency. In rodent models, diets low in choline and methyl-groups result in spontaneous hepatocarcinomas. In human epidemiological studies, there are interesting data that suggest that this also may be the case for humans, especially those with SNPs that increase the dietary requirement for choline." @default.
• W2080614092 created "2016-06-24" @default.
• W2080614092 creator A5049333121 @default.
• W2080614092 date "2012-05-01" @default.
• W2080614092 modified "2023-10-13" @default.
• W2080614092 title "Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones" @default.
• W2080614092 cites W1487907530 @default.
• W2080614092 cites W1499899701 @default.
• W2080614092 cites W1538800803 @default.
• W2080614092 cites W1555953993 @default.
• W2080614092 cites W1583805120 @default.
• W2080614092 cites W1601987904 @default.
• W2080614092 cites W1874317773 @default.
• W2080614092 cites W1965037168 @default.
• W2080614092 cites W1965586048 @default.
• W2080614092 cites W1966264011 @default.
• W2080614092 cites W1973519048 @default.
• W2080614092 cites W1975325378 @default.
• W2080614092 cites W1975357381 @default.
• W2080614092 cites W1977758605 @default.
• W2080614092 cites W1979995254 @default.
• W2080614092 cites W1982556586 @default.
• W2080614092 cites W1983496733 @default.
• W2080614092 cites W1998385675 @default.
• W2080614092 cites W2008662621 @default.
• W2080614092 cites W2010645487 @default.
• W2080614092 cites W2011829816 @default.
• W2080614092 cites W2020915761 @default.
• W2080614092 cites W2021836517 @default.
• W2080614092 cites W2023168595 @default.
• W2080614092 cites W2028294233 @default.
• W2080614092 cites W2029030998 @default.
• W2080614092 cites W2029723755 @default.
• W2080614092 cites W2032017606 @default.
• W2080614092 cites W2033598940 @default.
• W2080614092 cites W2036639432 @default.
• W2080614092 cites W2038108954 @default.
• W2080614092 cites W2040648203 @default.
• W2080614092 cites W2041930667 @default.
• W2080614092 cites W2044691771 @default.
• W2080614092 cites W2052102801 @default.
• W2080614092 cites W2053799987 @default.
• W2080614092 cites W2063148024 @default.
• W2080614092 cites W2065886025 @default.
• W2080614092 cites W2066355030 @default.
• W2080614092 cites W2070463636 @default.
• W2080614092 cites W2071772193 @default.
• W2080614092 cites W2073575123 @default.
• W2080614092 cites W2075528378 @default.
• W2080614092 cites W2077271774 @default.
• W2080614092 cites W2079584033 @default.
• W2080614092 cites W2089552551 @default.
• W2080614092 cites W2090670921 @default.
• W2080614092 cites W2092267358 @default.
• W2080614092 cites W2092366681 @default.
• W2080614092 cites W2095834666 @default.
• W2080614092 cites W2100489386 @default.
• W2080614092 cites W2107955062 @default.
• W2080614092 cites W2108210899 @default.
• W2080614092 cites W2110002004 @default.
• W2080614092 cites W2113119121 @default.
• W2080614092 cites W2113633315 @default.
• W2080614092 cites W2115210458 @default.
• W2080614092 cites W2121591739 @default.
• W2080614092 cites W2125457933 @default.
• W2080614092 cites W2128467815 @default.
• W2080614092 cites W2129930708 @default.
• W2080614092 cites W2138665109 @default.
• W2080614092 cites W2151547853 @default.
• W2080614092 cites W2153309340 @default.
• W2080614092 cites W2153551504 @default.
• W2080614092 cites W2154888525 @default.
• W2080614092 cites W2155572212 @default.
• W2080614092 cites W2155614484 @default.
• W2080614092 cites W2157736144 @default.
• W2080614092 cites W2159409293 @default.
• W2080614092 cites W2160089607 @default.
• W2080614092 cites W2160957891 @default.
• W2080614092 cites W2166757392 @default.
• W2080614092 cites W2167145211 @default.
• W2080614092 cites W2168035874 @default.
• W2080614092 cites W2168514417 @default.
• W2080614092 cites W2171139450 @default.
• W2080614092 cites W2220114233 @default.
• W2080614092 cites W2256935472 @default.
• W2080614092 cites W2265617634 @default.
• W2080614092 cites W4243179365 @default.
• W2080614092 doi "https://doi.org/10.1016/j.mrfmmm.2011.10.008" @default.
• W2080614092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3319504" @default.
• W2080614092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22041500" @default.
• W2080614092 hasPublicationYear "2012" @default.
• W2080614092 type Work @default.
• W2080614092 sameAs 2080614092 @default.
• W2080614092 citedByCount "88" @default.
• W2080614092 countsByYear W20806140922012 @default.
• W2080614092 countsByYear W20806140922013 @default.
• W2080614092 countsByYear W20806140922014 @default.
• W2080614092 countsByYear W20806140922015 @default.

• next