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• W2080615723 abstract "This study investigated the effects of exposure to ethanol during the brain growth spurt on a visual-discrimination (VD) and a place-learning task (PL) using intra-maze cues in the water maze. Artificially reared male Long–Evans rats were exposed to ethanol (ET) in a binge pattern from postnatal days 6–9 (6.5 g · kg−1 · day−1; BAC ∼330 mg/dl) or an isocaloric maltose–dextrin solution (gastrostomy control). A third suckled control group was reared by lactating dams. In experiment 1, rats were trained to discriminate horizontal- (H) versus vertical-striped (V) cues, with the positive cue providing escape from water. Groups did not differ with V+, but ET rats made more errors with H+. In experiment 2, the ET group was impaired in learning the spatial location of a submerged platform relative to intra-maze cues. In both tasks, acquisition deficits among ET rats were characterized by impairment emerging at trial 2, with intact reference memory on trial 1, and the ET group reached a comparable level of performance to controls by the end of training. In summary, because impairment was related to task characteristics, a clear distinction between impaired spatial- versus cue-based learning was not supported. However, these findings do support an effect of exposure to ethanol during the brain growth spurt on recent event, but not reference, memory." @default.
• W2080615723 created "2016-06-24" @default.
• W2080615723 creator A5034869668 @default.
• W2080615723 creator A5081714158 @default.
• W2080615723 date "2002-08-01" @default.
• W2080615723 modified "2023-09-26" @default.
• W2080615723 title "Testing the spatial- versus object-learning distinction: water-maze performance of male rats exposed to ethanol during the brain growth spurt" @default.
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• W2080615723 doi "https://doi.org/10.1016/s0166-4328(02)00091-8" @default.
• W2080615723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12191836" @default.
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