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- W2080619623 abstract "The metabolism and distribution of [2-14C]- and 35S-labelled 3,4-epithiobutanenitrile (4ETN), a thiirane occurring naturally in cruciferous vegetables, was studied in the rat. A dose of c. 11 mg 4ETN/kg body weight was rapidly transformed into water-soluble compounds and was mainly excreted in the urine, irrespective of the route of administration (oral or ip). The main metabolite in the urine was identified by gas chromatography-mass spectrometry as a mercapturic acid derivative. Low residual radioactivity demonstrated in organs 72 hr after administration was consistent with an earlier report that the thiirane may function as a weak biological alkylating agent." @default.
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- W2080619623 date "1984-03-01" @default.
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- W2080619623 title "Metabolism and distribution of 3,4-epithiobutanenitrile in the rat" @default.
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- W2080619623 doi "https://doi.org/10.1016/0278-6915(84)90132-7" @default.
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