Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080623364> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2080623364 endingPage "611" @default.
- W2080623364 startingPage "605" @default.
- W2080623364 abstract "Fungal infections represent a difficult challenge to clinicians caring for neutropenic patients with hematologic malignancies, as antifungal therapy often has limited success in that setting. One promising yet problematic alternative approach is leukocyte transfusion. The isolation of polymorphonuclear leukocytes (PMNs) induces apoptosis and functional deterioration, and irradiation to prevent transfusion-associated graft-versus-host disease causes further functional deterioration.The ability of interferon-gamma and granulocyte-colony-stimulating factor (G-CSF), used both alone and in combination, to protect PMNs after 0 or 20 hours' storage in cell culture (as a model for function after transfusion) and irradiation with 0, 5, or 30 Gy was studied.Without cytokine treatment, 20-hour-old PMNs showed marked apoptosis, no appreciable chemotaxis, and no ability to kill Candida albicans. In contrast, cytokine treatment significantly reduced apoptosis and protected chemotaxis, C. albicans killing, and surface-receptor expression from both storage and irradiation. Although the majority of the benefit appeared to be due to G-CSF, consistent trends suggested better function of PMNs after combined treatment with interferon-gamma and G-CSF.Judicious use of cytokines may preserve PMN function. These findings have important implications for the transfusion of PMNs to cytopenic patients." @default.
- W2080623364 created "2016-06-24" @default.
- W2080623364 creator A5020722157 @default.
- W2080623364 creator A5021132220 @default.
- W2080623364 creator A5034451201 @default.
- W2080623364 creator A5039260055 @default.
- W2080623364 creator A5045132368 @default.
- W2080623364 creator A5085239759 @default.
- W2080623364 date "1995-07-01" @default.
- W2080623364 modified "2023-09-25" @default.
- W2080623364 title "Protection of human polymorphonuclear leukocyte function from the deleterious effects of isolation, irradiation, and storage by interferon-gamma and granulocyte-colony-stimulating factor" @default.
- W2080623364 doi "https://doi.org/10.1046/j.1537-2995.1995.35795357886.x" @default.
- W2080623364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7543223" @default.
- W2080623364 hasPublicationYear "1995" @default.
- W2080623364 type Work @default.
- W2080623364 sameAs 2080623364 @default.
- W2080623364 citedByCount "37" @default.
- W2080623364 countsByYear W20806233642022 @default.
- W2080623364 crossrefType "journal-article" @default.
- W2080623364 hasAuthorship W2080623364A5020722157 @default.
- W2080623364 hasAuthorship W2080623364A5021132220 @default.
- W2080623364 hasAuthorship W2080623364A5034451201 @default.
- W2080623364 hasAuthorship W2080623364A5039260055 @default.
- W2080623364 hasAuthorship W2080623364A5045132368 @default.
- W2080623364 hasAuthorship W2080623364A5085239759 @default.
- W2080623364 hasConcept C126322002 @default.
- W2080623364 hasConcept C170493617 @default.
- W2080623364 hasConcept C190283241 @default.
- W2080623364 hasConcept C203014093 @default.
- W2080623364 hasConcept C2776178377 @default.
- W2080623364 hasConcept C2776694085 @default.
- W2080623364 hasConcept C2777767877 @default.
- W2080623364 hasConcept C2777983669 @default.
- W2080623364 hasConcept C2778690821 @default.
- W2080623364 hasConcept C2780841837 @default.
- W2080623364 hasConcept C2780917455 @default.
- W2080623364 hasConcept C54166955 @default.
- W2080623364 hasConcept C55493867 @default.
- W2080623364 hasConcept C71924100 @default.
- W2080623364 hasConcept C86803240 @default.
- W2080623364 hasConcept C89423630 @default.
- W2080623364 hasConceptScore W2080623364C126322002 @default.
- W2080623364 hasConceptScore W2080623364C170493617 @default.
- W2080623364 hasConceptScore W2080623364C190283241 @default.
- W2080623364 hasConceptScore W2080623364C203014093 @default.
- W2080623364 hasConceptScore W2080623364C2776178377 @default.
- W2080623364 hasConceptScore W2080623364C2776694085 @default.
- W2080623364 hasConceptScore W2080623364C2777767877 @default.
- W2080623364 hasConceptScore W2080623364C2777983669 @default.
- W2080623364 hasConceptScore W2080623364C2778690821 @default.
- W2080623364 hasConceptScore W2080623364C2780841837 @default.
- W2080623364 hasConceptScore W2080623364C2780917455 @default.
- W2080623364 hasConceptScore W2080623364C54166955 @default.
- W2080623364 hasConceptScore W2080623364C55493867 @default.
- W2080623364 hasConceptScore W2080623364C71924100 @default.
- W2080623364 hasConceptScore W2080623364C86803240 @default.
- W2080623364 hasConceptScore W2080623364C89423630 @default.
- W2080623364 hasIssue "7" @default.
- W2080623364 hasLocation W20806233641 @default.
- W2080623364 hasLocation W20806233642 @default.
- W2080623364 hasOpenAccess W2080623364 @default.
- W2080623364 hasPrimaryLocation W20806233641 @default.
- W2080623364 hasRelatedWork W1564746111 @default.
- W2080623364 hasRelatedWork W1986234548 @default.
- W2080623364 hasRelatedWork W2060657615 @default.
- W2080623364 hasRelatedWork W2080623364 @default.
- W2080623364 hasRelatedWork W2118200113 @default.
- W2080623364 hasRelatedWork W2131065804 @default.
- W2080623364 hasRelatedWork W2133162537 @default.
- W2080623364 hasRelatedWork W2891704995 @default.
- W2080623364 hasRelatedWork W4231796441 @default.
- W2080623364 hasRelatedWork W4233123208 @default.
- W2080623364 hasVolume "35" @default.
- W2080623364 isParatext "false" @default.
- W2080623364 isRetracted "false" @default.
- W2080623364 magId "2080623364" @default.
- W2080623364 workType "article" @default.