Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080632366> ?p ?o ?g. }
- W2080632366 endingPage "709" @default.
- W2080632366 startingPage "697" @default.
- W2080632366 abstract "Cell survival is determined by a balance among signaling cascades, including those that recruit the Akt and JNK pathways. Here we describe a novel interaction between Akt1 and JNK interacting protein 1 (JIP1), a JNK pathway scaffold. Direct association between Akt1 and JIP1 was observed in primary neurons. Neuronal exposure to an excitotoxic stimulus decreased the Akt1-JIP1 interaction and concomitantly increased association between JIP1 and JNK. Akt1 interaction with JIP1 inhibited JIP1-mediated potentiation of JNK activity by decreasing JIP1 binding to specific JNK pathway kinases. Consistent with this view, neurons from Akt1-deficient mice exhibited higher susceptibility to kainate than wild-type littermates. Overexpression of Akt1 mutants that bind JIP1 reduced excitotoxic apoptosis. These results suggest that Akt1 binding to JIP1 acts as a regulatory gate preventing JNK activation, which is released under conditions of excitotoxic injury." @default.
- W2080632366 created "2016-06-24" @default.
- W2080632366 creator A5000906756 @default.
- W2080632366 creator A5013656176 @default.
- W2080632366 creator A5028100054 @default.
- W2080632366 creator A5031484184 @default.
- W2080632366 creator A5068110148 @default.
- W2080632366 creator A5074113028 @default.
- W2080632366 creator A5078832342 @default.
- W2080632366 creator A5083842270 @default.
- W2080632366 date "2002-08-01" @default.
- W2080632366 modified "2023-10-16" @default.
- W2080632366 title "Akt1 Regulates a JNK Scaffold during Excitotoxic Apoptosis" @default.
- W2080632366 cites W1491979926 @default.
- W2080632366 cites W1496297920 @default.
- W2080632366 cites W1530284699 @default.
- W2080632366 cites W1567753257 @default.
- W2080632366 cites W1648092162 @default.
- W2080632366 cites W1675859815 @default.
- W2080632366 cites W1858533191 @default.
- W2080632366 cites W1890393292 @default.
- W2080632366 cites W1908445283 @default.
- W2080632366 cites W1967218150 @default.
- W2080632366 cites W1969134590 @default.
- W2080632366 cites W1973227020 @default.
- W2080632366 cites W1973914231 @default.
- W2080632366 cites W1974140472 @default.
- W2080632366 cites W1975995347 @default.
- W2080632366 cites W1976385326 @default.
- W2080632366 cites W1979909416 @default.
- W2080632366 cites W1981434339 @default.
- W2080632366 cites W1988568426 @default.
- W2080632366 cites W1997966434 @default.
- W2080632366 cites W2000664807 @default.
- W2080632366 cites W2022762164 @default.
- W2080632366 cites W2024306318 @default.
- W2080632366 cites W2030573603 @default.
- W2080632366 cites W2035147500 @default.
- W2080632366 cites W2040069783 @default.
- W2080632366 cites W2040143421 @default.
- W2080632366 cites W2044097681 @default.
- W2080632366 cites W2045214083 @default.
- W2080632366 cites W2045929031 @default.
- W2080632366 cites W2047604959 @default.
- W2080632366 cites W2048121649 @default.
- W2080632366 cites W2048688619 @default.
- W2080632366 cites W2058138221 @default.
- W2080632366 cites W2062390485 @default.
- W2080632366 cites W2065400512 @default.
- W2080632366 cites W2065671606 @default.
- W2080632366 cites W2068248480 @default.
- W2080632366 cites W2072018900 @default.
- W2080632366 cites W2076485183 @default.
- W2080632366 cites W2085273994 @default.
- W2080632366 cites W2086507786 @default.
- W2080632366 cites W2094068658 @default.
- W2080632366 cites W2096910934 @default.
- W2080632366 cites W2097293665 @default.
- W2080632366 cites W2097767970 @default.
- W2080632366 cites W2101422485 @default.
- W2080632366 cites W2101704246 @default.
- W2080632366 cites W2102369096 @default.
- W2080632366 cites W2111252945 @default.
- W2080632366 cites W2119807130 @default.
- W2080632366 cites W2123619341 @default.
- W2080632366 cites W2129108032 @default.
- W2080632366 cites W2130227962 @default.
- W2080632366 cites W2137035181 @default.
- W2080632366 cites W2140851951 @default.
- W2080632366 cites W2147103035 @default.
- W2080632366 cites W2147114673 @default.
- W2080632366 cites W2147242602 @default.
- W2080632366 cites W2155483393 @default.
- W2080632366 cites W29946730 @default.
- W2080632366 doi "https://doi.org/10.1016/s0896-6273(02)00821-8" @default.
- W2080632366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12194869" @default.
- W2080632366 hasPublicationYear "2002" @default.
- W2080632366 type Work @default.
- W2080632366 sameAs 2080632366 @default.
- W2080632366 citedByCount "201" @default.
- W2080632366 countsByYear W20806323662012 @default.
- W2080632366 countsByYear W20806323662013 @default.
- W2080632366 countsByYear W20806323662014 @default.
- W2080632366 countsByYear W20806323662015 @default.
- W2080632366 countsByYear W20806323662016 @default.
- W2080632366 countsByYear W20806323662017 @default.
- W2080632366 countsByYear W20806323662018 @default.
- W2080632366 countsByYear W20806323662019 @default.
- W2080632366 countsByYear W20806323662020 @default.
- W2080632366 countsByYear W20806323662021 @default.
- W2080632366 countsByYear W20806323662022 @default.
- W2080632366 countsByYear W20806323662023 @default.
- W2080632366 crossrefType "journal-article" @default.
- W2080632366 hasAuthorship W2080632366A5000906756 @default.
- W2080632366 hasAuthorship W2080632366A5013656176 @default.
- W2080632366 hasAuthorship W2080632366A5028100054 @default.
- W2080632366 hasAuthorship W2080632366A5031484184 @default.
- W2080632366 hasAuthorship W2080632366A5068110148 @default.