FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080632988> ?p ?o ?g. }

• W2080632988 endingPage "e1000466" @default.
• W2080632988 startingPage "e1000466" @default.
• W2080632988 abstract "Cytotoxic T lymphocytes (CTLs) are important immune effectors against intra-cellular pathogens. These cells search for infected cells and kill them. Recently developed experimental methods in combination with mathematical models allow for the quantification of the efficacy of CTL killing in vivo and, hence, for the estimation of parameters that characterize the effect of CTL killing on the target cell populations. It is not known how these population-level parameters relate to single-cell properties. To address this question, we developed a three-dimensional cellular automaton model of the region of the spleen where CTL killing takes place. The cellular automaton model describes the movement of different cell populations and their interactions. Cell movement patterns in our cellular automaton model agree with observations from two-photon microscopy. We find that, despite the strong spatial nature of the kinetics in our cellular automaton model, the killing of target cells by CTLs can be described by a term which is linear in the target cell frequency and saturates with respect to the CTL levels. Further, we find that the parameters describing CTL killing on the population level are most strongly impacted by the time a CTL needs to kill a target cell. This suggests that the killing of target cells, rather than their localization, is the limiting step in CTL killing dynamics given reasonable frequencies of CTL. Our analysis identifies additional experimental directions which are of particular importance to interpret estimates of killing rates and could advance our quantitative understanding of CTL killing." @default.
• W2080632988 created "2016-06-24" @default.
• W2080632988 creator A5009994638 @default.
• W2080632988 creator A5058044076 @default.
• W2080632988 date "2009-08-21" @default.
• W2080632988 modified "2023-09-25" @default.
• W2080632988 title "Investigating CTL Mediated Killing with a 3D Cellular Automaton" @default.
• W2080632988 cites W1571079964 @default.
• W2080632988 cites W1896786295 @default.
• W2080632988 cites W1983030109 @default.
• W2080632988 cites W1994500037 @default.
• W2080632988 cites W1998334143 @default.
• W2080632988 cites W2002062046 @default.
• W2080632988 cites W2007988618 @default.
• W2080632988 cites W2015776459 @default.
• W2080632988 cites W2020491131 @default.
• W2080632988 cites W2022378244 @default.
• W2080632988 cites W2030779733 @default.
• W2080632988 cites W2040996563 @default.
• W2080632988 cites W2044555293 @default.
• W2080632988 cites W2056703680 @default.
• W2080632988 cites W2062478481 @default.
• W2080632988 cites W2063220206 @default.
• W2080632988 cites W2065161565 @default.
• W2080632988 cites W2066096730 @default.
• W2080632988 cites W2068838772 @default.
• W2080632988 cites W2080539640 @default.
• W2080632988 cites W2082008999 @default.
• W2080632988 cites W2088129901 @default.
• W2080632988 cites W2099182602 @default.
• W2080632988 cites W2100994301 @default.
• W2080632988 cites W2107111117 @default.
• W2080632988 cites W2121931877 @default.
• W2080632988 cites W2134916334 @default.
• W2080632988 cites W2139801521 @default.
• W2080632988 cites W2141258913 @default.
• W2080632988 cites W2146322847 @default.
• W2080632988 cites W2149928606 @default.
• W2080632988 cites W2157605910 @default.
• W2080632988 cites W2165143211 @default.
• W2080632988 cites W2166329493 @default.
• W2080632988 cites W2167670122 @default.
• W2080632988 cites W2170831273 @default.
• W2080632988 doi "https://doi.org/10.1371/journal.pcbi.1000466" @default.
• W2080632988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2715871" @default.
• W2080632988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19696876" @default.
• W2080632988 hasPublicationYear "2009" @default.
• W2080632988 type Work @default.
• W2080632988 sameAs 2080632988 @default.
• W2080632988 citedByCount "48" @default.
• W2080632988 countsByYear W20806329882012 @default.
• W2080632988 countsByYear W20806329882013 @default.
• W2080632988 countsByYear W20806329882014 @default.
• W2080632988 countsByYear W20806329882015 @default.
• W2080632988 countsByYear W20806329882016 @default.
• W2080632988 countsByYear W20806329882017 @default.
• W2080632988 countsByYear W20806329882018 @default.
• W2080632988 countsByYear W20806329882019 @default.
• W2080632988 countsByYear W20806329882020 @default.
• W2080632988 countsByYear W20806329882021 @default.
• W2080632988 countsByYear W20806329882022 @default.
• W2080632988 countsByYear W20806329882023 @default.
• W2080632988 crossrefType "journal-article" @default.
• W2080632988 hasAuthorship W2080632988A5009994638 @default.
• W2080632988 hasAuthorship W2080632988A5058044076 @default.
• W2080632988 hasBestOaLocation W20806329881 @default.
• W2080632988 hasConcept C11413529 @default.
• W2080632988 hasConcept C147969180 @default.
• W2080632988 hasConcept C1491633281 @default.
• W2080632988 hasConcept C154317977 @default.
• W2080632988 hasConcept C202751555 @default.
• W2080632988 hasConcept C2908647359 @default.
• W2080632988 hasConcept C35527583 @default.
• W2080632988 hasConcept C41008148 @default.
• W2080632988 hasConcept C54355233 @default.
• W2080632988 hasConcept C71924100 @default.
• W2080632988 hasConcept C86803240 @default.
• W2080632988 hasConcept C95444343 @default.
• W2080632988 hasConcept C99454951 @default.
• W2080632988 hasConceptScore W2080632988C11413529 @default.
• W2080632988 hasConceptScore W2080632988C147969180 @default.
• W2080632988 hasConceptScore W2080632988C1491633281 @default.
• W2080632988 hasConceptScore W2080632988C154317977 @default.
• W2080632988 hasConceptScore W2080632988C202751555 @default.
• W2080632988 hasConceptScore W2080632988C2908647359 @default.
• W2080632988 hasConceptScore W2080632988C35527583 @default.
• W2080632988 hasConceptScore W2080632988C41008148 @default.
• W2080632988 hasConceptScore W2080632988C54355233 @default.
• W2080632988 hasConceptScore W2080632988C71924100 @default.
• W2080632988 hasConceptScore W2080632988C86803240 @default.
• W2080632988 hasConceptScore W2080632988C95444343 @default.
• W2080632988 hasConceptScore W2080632988C99454951 @default.
• W2080632988 hasIssue "8" @default.
• W2080632988 hasLocation W20806329881 @default.
• W2080632988 hasLocation W20806329882 @default.
• W2080632988 hasLocation W20806329883 @default.
• W2080632988 hasLocation W20806329884 @default.
• W2080632988 hasLocation W20806329885 @default.

• next