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• W2080634533 abstract "Glycans, also known as complex sugars, can be engineered in any number of ways. They can be designed to glow, and illuminating the small molecules is a challenge accepted by Carolyn Bertozzi.Carolyn Bertozzi.Bertozzi, who was elected to the National Academy of Sciences in 2005, has spent much of her career devising methods to visualize glycans inside living organisms. Although glycans are critical participants in cell–cell adhesion and help mediate the mammalian immune system, the biopolymers are not directly genetically encoded and are therefore difficult to label using typical biochemical methods such as lectin and antibody labeling.The search for glycans in their natural environment has proven elusive even to Bertozzi, recipient of the prestigious MacArthur Fellowship in 1999, among a litany of other honors and awards.In her Inaugural Article, published in the January 6, 2009, issue of PNAS, Bertozzi and her coauthor Scott Laughlin demonstrate a process that images glycans inside living zebrafish embryos without perturbing the natural function of the target molecule (1).By adding small, biologically inert chemical reporters that get incorporated as the sugar is built, the method provides a functional handle for subsequent attachment of fluorescent probes via a chemical reaction that takes place inside the organism.Born in 1966, Bertozzi grew up in Lexington, Massachusetts. Her father, William, was a physics professor at Massachusetts Institute of Technology (MIT, Cambridge, MA).“Science was focus of the house,” she says. “We wore MIT T-shirts and went to MIT day camp.”When teachers asked Bertozzi and her two sisters what they wanted to be, Bertozzi remembers that their answers were “nuclear physicist.”Their father often asked where they were going to get their Ph.D.’s, Bertozzi recalls. “He had this idea that all three of us would go to MIT—a mixture of pride and the …" @default.
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• W2080634533 date "2010-02-16" @default.
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• W2080634533 title "Profile of Carolyn Bertozzi" @default.
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• W2080634533 doi "https://doi.org/10.1073/pnas.0914469107" @default.
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