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- W2080634591 abstract "One day after ligation of the canine anterior descending coronary artery, clofilium, a long-acting class III anti-arrhythmic agent, was studied for its effects on normal and ischemic Purkinje fibers. In normal Tyrode's solution (4 mMpotassium, 2.7 mMcalcium) clofilium (10−7to 10−5M) increased action potential duration. Although only 2 of 10 normal Purkinje fibers developed early afterdepolarizations and early afterdepolarization-initiated triggered activity, 10 of 11 ischemic Purkinje fibers developed these features. Consequently, action potentials in ischemic fibers were prolonged to durations >10 s. The triggered activity in the ischemic Purkinje fibers produced repetitive activity in adjacent normal ventricular muscle. In vivo, 3 days after ligation, the administration of 3 to 10 mg/kg clofilium induced grouped beating. Action potentials recorded subsequently from these same hearts in vitro showed early afterdepolarizations, triggered activity and a similar grouping of responses. Therefore, clofilium differentially produced early afterdepolarizations in ischemic Purkinje fibers. This is a mechanism by which clofilium could be arrhythmogenic in an ischemic heart." @default.
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- W2080634591 date "1988-02-01" @default.
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- W2080634591 title "Effects of clofilium on ischemic subendocardial Purkinje fibers 1 day postinfarction" @default.
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- W2080634591 doi "https://doi.org/10.1016/0735-1097(88)90112-x" @default.
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